Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Glehr, M; Breisach, M; Walzer, S; Lohberger, B; Fürst, F; Friesenbichler, J; Rinner, B; Avian, A; Windhager, R; Leithner, A.
The influence of resveratrol on the synovial expression of matrix metalloproteinases and receptor activator of NF-kappaB ligand in rheumatoid arthritis fibroblast-like synoviocytes.
Z Naturforsch C. 2013; 68(7-8):336-342
Doi: 10.5560/ZNC.2013.68c0336
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Glehr Mathias
- Co-Autor*innen der Med Uni Graz
- Avian Alexander
- Friesenbichler Jörg
- Fritsch-Breisach Margherita
- Leithner Andreas
- Lohberger Birgit
- Moazedi-Fürst Florentine
- Rinner Beate
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- Abstract:
- Medication of rheumatoid arthritis (RA) remains challenging and often controversial concerning side effects or long-term complications. We investigated the effect of resveratrol, a phytoalexin discussed for its chondro-protective and anti-inflammatory qualities, on the synovial expression of matrix-degrading enzymes like matrix metalloproteinases (MMPs) and bone-remodelling proteins in RA fibroblast-like synoviocytes (FLS). Interleukin-1beta-stimulated RA-FLS were treated with 100 microM resveratrol for 24 h. To evaluate the effect of resveratrol on the amount of bound/combined MMPs, a Luminex xMAP multiplexing technology was used. The alteration in expression of receptor activator of nuclear factor-kappaB ligand (RANKL) and osteoprotegrin (OPG) was measured by quantitative real-time polymerase chain reaction (qRT-PCR). Resveratrol reduced the expression of MMP-1 (p = 0.022), MMP-3 (p = 0.021), and MMP-9 (p = 0.047). qRT-PCR showed a significant reduction in the relative abundance of the transcripts of OPG (p = 0.012) and RANKL (p = 0.018). Our in vitro findings indicate that resveratrol could be a new target for further pharmacological studies in the field of RA. In the future it could play a role as a possible substitute or supplement to currently used drugs against RA to prevent cartilage matrix degradation and pathological bone resorption due to inhibition of MMPs and RANKL.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Arthritis, Rheumatoid - metabolism
- Female -
- Humans -
- Male -
- Matrix Metalloproteinases - metabolism
- Middle Aged -
- RANK Ligand - metabolism
- Stilbenes - pharmacology
- Synovial Membrane - cytology
- Find related publications in this database (Keywords)
- Resveratrol
- Rheumatoid Arthritis
- Matrix Metalloproteinases