Medizinische Universität Graz - Research portal

Go directly to the nagivation.
Go directly to the content.

Navigation/Search

Selected Publication:

SHR Neuro Cancer Cardio Lipid Metab Microb

Palkovits, S; Fuchsjäger-Mayrl, G; Kautzky-Willer, A; Richter-Müksch, S; Prinz, A; Vécsei-Marlovits, V; Garhöfer, G; Schmetterer, L.
Retinal white blood cell flux and systemic blood pressure in patients with type 1 diabetes.
Graefes Arch Clin Exp Ophthalmol. 2013; 251(6):1475-1481 Doi: 10.1007/s00417-012-2193-3
Web of Science PubMed FullText FullText_MUG

Leading authors Med Uni Graz: Palkovits Stefan
Altmetrics:
Dimensions Citations:
Plum Analytics:
Scite (citation analytics):
Abstract:: There is evidence that altered retinal blood flow and altered retinal blood flow regulation play a role in the development and progression of diabetic retinopathy. We compared the association between systemic blood pressure and retinal white blood cell flux in patients with type 1 diabetes and healthy control subjects. The study was performed in 100 patients with type 1 diabetes with no or minimal diabetic retinopathy and a group of 313 age-matched healthy controls. Inclusion criteria were systolic blood pressure a parts per thousand currency sign160 mmHg and diastolic blood pressure a parts per thousand currency sign95 mmHg. None of the subjects took vasoactive medication except insulin. The blue field entoptic technique was used to assess retinal white blood cell flux, velocity and density in the perimacular region. Pressure-flow relationships were calculated for both groups to assess differences in blood flow regulation. Retinal white blood cell flux was comparable between the two study groups. Both type 1 diabetic patients and healthy subjects showed a significant positive correlation between retinal white blood cell flux and mean arterial pressure (diabetic patients: r = 0.48; p < 0.05, healthy subjects r = 0.28). The correlation coefficients between mean arterial pressure and white blood cell flux were significantly higher in patients with diabetes than in the healthy control group (p = 0.0459). Retinal white blood cell flux, as assessed with the blue-field entoptic technique, is not significantly different between type 1 diabetic patients with no or minimal retinopathy and healthy control subjects. Type 1 diabetic subjects do, however, show an abnormal association between systemic blood pressure and retinal white blood cell flux. This indicates altered autoregulation in early diabetic retinopathy.
Find related publications in this database (using NLM MeSH Indexing): Adult -; Blood Flow Velocity - physiology; Blood Glucose - metabolism; Blood Pressure - physiology; Diabetes Mellitus, Type 1 - physiopathology; Diabetic Retinopathy - physiopathology; Female -; Hemoglobin A, Glycosylated - metabolism; Homeostasis -; Humans -; Intraocular Pressure - physiology; Laser-Doppler Flowmetry -; Leukocytes - physiology; Male -; Middle Aged -; Retinal Vessels - physiopathology; Tonometry, Ocular -; Young Adult -
Find related publications in this database (Keywords): Diabetes; Retinal blood flow autoregulation; Systemic blood pressure; Blue-field entoptic technique