Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
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SHR Neuro Krebs Kardio Lipid Stoffw Microb
Schmidl, D; Pemp, B; Lasta, M; Boltz, A; Kaya, S; Palkovits, S; Prager, F; Schmetterer, L; Garhofer, G.
Effects of orally administered moxaverine on ocular blood flow in healthy subjects.
Graefes Arch Clin Exp Ophthalmol. 2013; 251(2): 515-520.
Doi: 10.1007/s00417-012-2207-1
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- Co-Autor*innen der Med Uni Graz
- Palkovits Stefan
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- Abstract:
- To investigate the effect of orally administered moxaverine (Kollateral forteA (R)) on ocular blood flow in young healthy subjects. Sixteen healthy subjects (eight male/eight female) aged between 20 and 32 years were included in this placebo-controlled, double-masked, two-way crossover study. Volunteers received 900 mg moxaverine-hydrochloride administered orally in three equal doses or placebo identical in appearance on 2 study days. Outcome variables were measured at baseline and 5 h after first drug administration. Laser Doppler flowmetry was used to assess choroidal and optic nerve head blood flow. Blood velocities in the retrobulbar vessels were measured with color Doppler imaging. Neither moxaverine nor placebo changed mean arterial pressure or intraocular pressure. Neither moxaverine nor placebo had an effect on choroidal (moxaverine: by 9.5 +/- 17.2 %, placebo 3.8 +/- 18.8 %, p = 0.54 between groups) or optic nerve head blood flow (moxaverine: 4.8 +/- 10.4 %, placebo: 1.8 +/- 10.9 %, p = 0.52 between groups). Similarly, administration of moxaverine did not change blood flow velocities or calculated resistance index in the retrobulbar vessels compared to placebo. The data of the present study indicate that orally administered moxaverine does not increase ocular blood flow. This is in contrast to previous findings, where parenteral administration of moxaverine lead to a significant increase in choroidal blood flow and blood flow velocities in the retrobulbar vessels. The reason for these differing results is unclear, but may be related to the low bioavailability after oral administration.
- Find related publications in this database (using NLM MeSH Indexing)
- Administration, Oral -
- Adult -
- Blood Flow Velocity - drug effects
- Blood Pressure - drug effects
- Choroid - blood supply
- Ciliary Arteries - physiology
- Cross-Over Studies -
- Double-Blind Method -
- Female -
- Humans -
- Intraocular Pressure - drug effects
- Laser-Doppler Flowmetry -
- Male -
- Ophthalmic Artery - physiology
- Optic Disk - blood supply
- Papaverine - administration & dosage
- Parasympatholytics - administration & dosage
- Regional Blood Flow - drug effects
- Retinal Artery - physiology
- Ultrasonography, Doppler, Color -
- Young Adult -
- Find related publications in this database (Keywords)
- Moxaverine
- Ocular blood flow
- Laser doppler flowmetry
- Color doppler imaging