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Eber, B; Schumacher, M; Auergrumbach, P; Toplak, H; Klein, W.
Increased IgM-anticardiolipin antibodies in patients with restenosis after percutaneous transluminal coronary angioplasty.
Am J Cardiol. 1992; 69(16):1255-1258 Doi: 10.1016/0002-9149(92)91216-Q
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Co-authors Med Uni Graz: Schumacher Martin; Toplak Hermann
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Abstract:: Increased anticardiolipin antibodies (acL) are often associated with arterial thrombosis in patients with autoimmune diseases. A mural thrombus at the site of percutaneous transluminal coronary angioplasty (PTCA) has been suggested as the initial cause for restenosis after primarily successful PTCA. In this study, IgM- and IgG-acL were determined in 65 men with coronary artery disease treated by PTCA; patients with infectious and autoimmune diseases were excluded from the study. Follow-up coronary angiography was performed 12 months after PTCA; restenosis was defined as greater than or equal to 50% reduction in diameter of the coronary vessel. The series comprised 2 groups: 34 patients (mean age 56 +/- 8 years) with (group A) and 31 (mean age 55 +/- 9 years) without (group B) restenosis. Medical history and laboratory findings were comparable in both groups. In patients with restenosis, IgM-acL were more often increased (9 of 34) than were those in patients without restenosis (2 of 31; p less than 0.05); IgG-acL values did not differ in both groups. Furthermore, there was no correlation between any vascular risk factors or laboratory findings, or both, with both IgM- and IgG-acL levels. Thus, IgM-acL appear to be independent indicators for an increased risk for restenosis after PTCA. Our observations suggest that an autoimmune mechanism may have a role in restenosis.
Find related publications in this database (using NLM MeSH Indexing): Adult -; Aged -; Angioplasty, Transluminal, Percutaneous Coronary -; Autoantibodies - blood; Cardiolipins - blood; Chi-Square Distribution -; Coronary Disease - immunologyCoronary Disease - therapy; Humans -; Immunoglobulin G - blood; Immunoglobulin Isotypes - blood; Immunoglobulin M - blood; Male -; Middle Aged -; Recurrence -; Risk Factors -