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Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Kralemann, B; Frühwirth, M; Pikovsky, A; Rosenblum, M; Kenner, T; Schaefer, J; Moser, M.
In vivo cardiac phase response curve elucidates human respiratory heart rate variability.
Nat Commun. 2013; 4(10):2418-2418
Doi: 10.1038/ncomms3418
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- Co-authors Med Uni Graz
- Kenner Thomas
- Moser Maximilian
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- Abstract:
- Recovering interaction of endogenous rhythms from observations is challenging, especially if a mathematical model explaining the behaviour of the system is unknown. The decisive information for successful reconstruction of the dynamics is the sensitivity of an oscillator to external influences, which is quantified by its phase response curve. Here we present a technique that allows the extraction of the phase response curve from a non-invasive observation of a system consisting of two interacting oscillators--in this case heartbeat and respiration--in its natural environment and under free-running conditions. We use this method to obtain the phase-coupling functions describing cardiorespiratory interactions and the phase response curve of 17 healthy humans. We show for the first time the phase at which the cardiac beat is susceptible to respiratory drive and extract the respiratory-related component of heart rate variability. This non-invasive method for the determination of phase response curves of coupled oscillators may find application in many scientific disciplines.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aging - physiology
- Electrocardiography -
- Female -
- Heart - physiology
- Heart Rate - physiology
- Humans -
- Male -
- Middle Aged -
- Pulse -
- Respiration -
- Signal Processing, Computer-Assisted -