Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Holzer, LA; Cör, A; Pfandlsteiner, G; Holzer, G.
Expression of VEGF, its receptors, and HIF-1α in Dupuytren's disease.
Acta Orthop. 2013; 84(4):420-425
Doi: 10.3109/17453674.2013.814011
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- Führende Autor*innen der Med Uni Graz
- Holzer Lukas
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- Abstract:
- Background and purpose - Dupuytren's disease (DD) is a benign fibroproliferative process that affects the palmar fascia. The pathology of DD shows similarities with wound healing and tumor growth; hypoxia and angiogenesis play important roles in both. We investigated the role of angiogenic proteins in DD. Patients and methods - The expression of vascular endothelial growth factor (VEGF), its receptors vascular endothelial growth factor receptor 1 (VEGFR1) and vascular endothelial growth factor receptor 2 (VEGFR2), hypoxia-inducible factor alfa (HIF-1 alpha), and alfa-smooth muscle actin (alpha-SMA) were analyzed immunohistochemically in fragments of excised Dupuytren's tissue from 32 patients. We compared these values to values for expression in a control group. Results - 15 of 32 samples could be attributed to the involutional phase (alpha-SMA positive), whereas 17 samples were considered to be cords at the residual phase (alpha-SMA negative). In the involutional phase, the HIF-1 alpha and VEGFR2 expression was statistically significantly higher than in the residual phase and in the controls. Interpretation - Both the VEGFR2 receptor and HIF-1 alpha were expressed in alpha-SMA positive myofibroblast-rich nodules with characteristics of DD in the active involutional phase. Thus, hypoxia and (subsequently) angiogenesis may have a role in the pathophysiology of DD.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Aged, 80 and over -
- Dupuytren Contracture - metabolism
- Female -
- Humans -
- Hypoxia-Inducible Factor 1, alpha Subunit - metabolism
- Immunohistochemistry -
- Male -
- Middle Aged -
- Neovascularization, Pathologic - metabolism
- Vascular Endothelial Growth Factor A - metabolism
- Vascular Endothelial Growth Factor Receptor-1 - metabolism
- Vascular Endothelial Growth Factor Receptor-2 - metabolism