Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Tomazic, PV; Stammberger, H; Habermann, W; Schmid, C; Koele, W; Mokry, M; Gellner, V; Beham, A.
Aggressive inverted papilloma with intracranial invasion and short malignization time.
Skull Base Rep. 2011; 1(2):111-114
Doi: 10.1055/s-0031-1280738
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- Führende Autor*innen der Med Uni Graz
- Tomazic Peter Valentin
- Co-Autor*innen der Med Uni Graz
- Beham Alfred
- Gellner Verena
- Habermann Walter
- Köle Wolfgang
- Mokry Michael
- Schmid Christoph Michael
- Stammberger Heinz
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- Abstract:
- Inverted papillomas (IP) are considered benign lesions with a prevalence up to 4% among all sinunasal tumors; however, invasive growth and varying tendency for malignization are reported in literature. We report the case of a 69-year-old woman suffering from a large, aggressively growing IP invading the orbit, skull base, and frontal lobe of the brain. Within only 3 months' time the papilloma showed transformation into an invasive carcinoma, leaving surgical therapy in vain due to explosive recurrence. Intracranial and intraorbital expansion by IP is possible despite histology not showing signs of malignancy initially. In "regular" IP close endoscopic follow-up is mandatory to not overlook recurrence harboring malignancy.