Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Pienn, M; Kovacs, G; Tscherner, M; Johnson, TR; Kullnig, P; Stollberger, R; Olschewski, A; Olschewski, H; Bálint, Z.
Determination of cardiac output with dynamic contrast-enhanced computed tomography.
Int J Cardiovasc Imaging. 2013; 29(8):1871-1878
Doi: 10.1007/s10554-013-0279-6
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PubMed
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- Führende Autor*innen der Med Uni Graz
- Balint Zoltan
- Pienn Michael
- Co-Autor*innen der Med Uni Graz
- Kovacs Gabor
- Olschewski Andrea
- Olschewski Horst
- Stollberger Rudolf
- Tscherner Maria
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- Abstract:
- Cardiac output (CO) is an important diagnostic and prognostic factor in the haemodynamic evaluation of patients. The gold standard for CO measurement, thermodilution, requires an invasive right-heart catheterisation (RHC). In this pilot study we aimed to determine the accuracy of non-invasive CO determination from dynamic contrast-enhanced computed tomography (CT) compared to thermodilution. Patients who underwent diagnostic or follow-up RHC due to suspected or known pulmonary vascular disease at our department and required a thoracic CT between June 2011 and August 2012 were included. CO was determined from CT attenuation-time curves in the pulmonary artery and the ascending aorta using a dynamic contrast-enhanced CT sequence. CO determined in N = 18 patients by dynamic CT in the pulmonary artery was in very good agreement with thermodilution data (r = 0.84). Bland-Altman analysis showed a systematic overestimation of 0.7 ± 0.6 l/min compared to thermodilution. Data from the ascending aorta also showed a good correlation, but with a larger scattering of the values. The average effective dose for the dynamic investigation was 1.2 ± 0.7 mSv. CO determined with dynamic contrast-enhanced CT in the main pulmonary artery reliably predicts the values obtained by thermodilution during RHC. This non-invasive technique might provide an alternative for repeated invasive right-heart catheter investigations in the follow-up of pulmonary arterial hypertension patients.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Aorta - physiopathology
- Aortography -
- Cardiac Catheterization -
- Cardiac Output -
- Contrast Media - diagnostic use
- Familial Primary Pulmonary Hypertension -
- Female -
- Humans -
- Hypertension, Pulmonary - physiopathology
- Iohexol - analogs & derivatives
- Male -
- Middle Aged -
- Pilot Projects -
- Predictive Value of Tests -
- Pulmonary Artery - physiopathology
- Radiation Dosage -
- Radiographic Image Interpretation, Computer-Assisted -
- Reproducibility of Results -
- Thermodilution -
- Time Factors -
- Tomography, X-Ray Computed -
- Find related publications in this database (Keywords)
- Non-invasive
- Right-heart catheterisation
- Thermodilution
- Indicator dilution theory