Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Pellicer, A; Greisen, G; Benders, M; Claris, O; Dempsey, E; Fumagalli, M; Gluud, C; Hagmann, C; Hellström-Westas, L; Hyttel-Sorensen, S; Lemmers, P; Naulaers, G; Pichler, G; Roll, C; van Bel, F; van Oeveren, W; Skoog, M; Wolf, M; Austin, T.
The SafeBoosC phase II randomised clinical trial: a treatment guideline for targeted near-infrared-derived cerebral tissue oxygenation versus standard treatment in extremely preterm infants.
Neonatology. 2013; 104(3):171-178
Doi: 10.1159/000351346
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- Co-authors Med Uni Graz
- Pichler Gerhard
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- Abstract:
- Near-infrared spectroscopy-derived regional tissue oxygen saturation of haemoglobin (rStO2) reflects venous oxygen saturation. If cerebral metabolism is stable, rStO2 can be used as an estimate of cerebral oxygen delivery. The SafeBoosC phase II randomised clinical trial hypothesises that the burden of hypo- and hyperoxia can be reduced by the combined use of close monitoring of the cerebral rStO2 and a treatment guideline to correct deviations in rStO2 outside a predefined target range. To describe the rationale for and content of this treatment guideline. Review of the literature and assessment of the quality of evidence and the grade of recommendation for each of the interventions. A clinical intervention algorithm based on the main determinants of cerebral perfusion-oxygenation changes during the first hours after birth was generated. The treatment guideline is presented to assist neonatologists in making decisions in relation to cerebral oximetry readings in preterm infants within the SafeBoosC phase II randomised clinical trial. The evidence grades were relatively low and the guideline cannot be recommended outside a research setting. © 2013 S. Karger AG, Basel.
- Find related publications in this database (using NLM MeSH Indexing)
- Algorithms -
- Brain - physiology
- Clinical Trials, Phase II as Topic - methods
- Humans -
- Infant, Extremely Premature - physiology
- Infant, Newborn -
- Oximetry - methods
- Oxygen - administration & dosage
- Practice Guidelines as Topic -
- Randomized Controlled Trials as Topic - methods
- Spectroscopy, Near-Infrared - standards
- Find related publications in this database (Keywords)
- Near-infrared spectroscopy
- Newborn
- Practice guideline
- Cardiovascular agents
- Hypotension
- Oxygen consumption
- Carbon dioxide
- Hyperoxia