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SHR Neuro Cancer Cardio Lipid Metab Microb
Baranyi, A; Meinitzer, A; Stepan, A; Putz-Bankuti, C; Breitenecker, RJ; Stauber, R; Kapfhammer, HP; Rothenhäusler, HB.
A biopsychosocial model of interferon-alpha-induced depression in patients with chronic hepatitis C infection.
Psychother Psychosom. 2013; 82(5):332-340
Doi: 10.1159/000348587
Web of Science
PubMed
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- Leading authors Med Uni Graz
- Baranyi Andreas
- Co-authors Med Uni Graz
- Kapfhammer Hans-Peter
- Meinitzer Andreas
- Putz-Bankuti Csilla
- Rothenhäusler Hans-Bernd
- Stauber Rudolf
- Stepan Alexandra
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- Abstract:
- Background: The aim of this prospective study was to gain a more comprehensive picture of the biopsychosocial effects of interferon-alpha (IFN-alpha) treatment of patients with chronic hepatitis C (HCV). The predictors of depressive development and changes in health-related quality of life, life satisfaction and cognitive ability were measured with the inclusion of the social context. Furthermore, the effects of IFN-alpha treatment on indoleamine 2,3-dioxygenase, the level of tryptophan supply in the brain, the development of neurotoxic kynurenine metabolites and the thyroid glands were investigated. Therefore, for the first time the conditions for the development of depressive episodes in HCV patients treated with IFN-alpha were examined over the entire period of treatment as well as 3 months later, applying a holistic biopsychosocial model. Method: Psychiatric and biological assessments were carried out at 6 different times: before, during (at 1, 3,6 and 9 months) and after the end of IFN-alpha treatment. Results: During IFN-alpha treatment 22 (53.7%) of 41 patients fulfilled the criteria for a treatment-related depressive disorder at least once during treatment. Contributing factors are tryptophan depletion (tryptophan to competing amino acids quotient), increased neurotoxic challenge (kynurenine to kynurenic acid quotient), less social support, female gender, preexisting psychiatric vulnerability, means of transmission, low financial security, impaired sexual satisfaction, small circle of friends, impaired physical role, strong body pain, low general health and vitality, reduced social functioning, impaired mental health and impaired emotional role. Conclusions:The awareness of relevant risk factors of IFN-alpha treatment-induced depression is essential to develop preventative treatment strategies. Copyright (C) 2013 S. Karger AG, Basel
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Analysis of Variance -
- Depressive Disorder - chemically induced
- Female -
- Hepatitis C, Chronic - drug therapy
- Humans -
- Indoleamine-Pyrrole 2,3,-Dioxygenase - drug effects
- Interferon-alpha - adverse effects
- Interview, Psychological -
- Kynurenic Acid - metabolism
- Kynurenine - metabolism
- Male -
- Models, Theoretical -
- Neuropsychological Tests - statistics & numerical data
- Personal Satisfaction -
- Prospective Studies -
- Psychiatric Status Rating Scales - statistics & numerical data
- Quality of Life -
- Questionnaires -
- Risk Factors -
- Sex Factors -
- Social Support -
- Thyroid Function Tests -
- Tryptophan - metabolism
- Find related publications in this database (Keywords)
- Hepatitis C
- Interferon-alpha
- Depression
- Tryptophan depletion
- Neurotoxic challenge
- Health-related quality of life
- Life satisfaction
- Social support
- Cognition