Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Ahlgrimm-Siess, V; Cao, T; Oliviero, M; Laimer, M; Hofmann-Wellenhof, R; Rabinovitz, HS; Scope, A; .
Seborrheic keratosis: Reflectance confocal microscopy features and correlation with dermoscopy.
J Am Acad Dermatol. 2013; 69(1):120-126
Doi: 10.1016/j.jaad.2012.12.969
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Ahlgrimm-Siess Verena
- Co-Autor*innen der Med Uni Graz
- Hofmann-Wellenhof Rainer
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- Background: Differentiation between seborrheic keratosis (SK) and skin cancers may be difficult. Reflectance confocal microscopy (RCM) enables noninvasive assessment of skin neoplasms at cellular-level resolution. Objective: We sought to describe RCM features of SK and to correlate these RCM findings with dermoscopic structures. Methods: Clinical, dermoscopic, and RCM images of 45 consecutive SK were obtained at a private and university dermatology clinic. Fourteen SK were biopsied because of equivocal clinical or dermoscopic features. Results: With RCM, all SK displayed a regular honeycomb pattern of the epidermis and densely packed, round to polymorphous, well-circumscribed dermal papillae at the dermoepidermal junction, features suggestive of a benign neoplasm. RCM features indicating the diagnosis of SK were also observed, including epidermal projections (43/45 SK; 96%) and keratin-filled invaginations (36/45 SK; 80%) at the lesion surface; corneal pseudocysts at epidermal layers (19/45 SK; 42%); and melanophages (21/45 SK; 47%) and dilated round and linear blood vessels (21/45 SK; 47%) in the papillary dermis. Of biopsied SK, 93% (13/14) displayed at least 3 characteristic RCM findings in the absence of RCM features suggestive of malignancy. Limitations: This was a limited study sample and retrospective study design. Conclusions: SK display a distinct set of RCM criteria despite their variable clinical and dermoscopic appearances.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Aged, 80 and over -
- Dermoscopy -
- Epidermis - pathology
- Female -
- Humans -
- Keratosis, Seborrheic - diagnosis
- Lentigo - pathology
- Male -
- Microscopy, Confocal - methods
- Middle Aged -
- Retrospective Studies -
- Skin Neoplasms - diagnosis
- Find related publications in this database (Keywords)
- dermoscopy
- histopathology
- in vivo reflectance confocal microscopy
- seborrheic keratoses
- solar lentigo