Medizinische Universität Graz - Research portal

Go directly to the nagivation.
Go directly to the content.

Navigation/Search

Selected Publication:

SHR Neuro Cancer Cardio Lipid Metab Microb

Nardone, R; Golaszewski, S; Höller, Y; Christova, M; Trinka, E; Brigo, F.
Neurophysiological insights into the pathophysiology of REM sleep behavior disorders: a review.
Neurosci Res. 2013; 76(3):106-112 Doi: 10.1016/j.neures.2013.03.009
Web of Science PubMed FullText FullText_MUG

Co-authors Med Uni Graz: Christova Monica
Altmetrics:
Dimensions Citations:
Plum Analytics:
Scite (citation analytics):
Abstract:: Rapid eye movement (REM) sleep behavior disorder (RBD) is a clinical condition characterized by an intermittent or complete loss of muscle atonia and an increase of phasic muscular activity during REM sleep (or Stage R), leading to complex nocturnal motor behaviors. Correct and early diagnosis is important because RBD may lead to serious injuries and is a well-treatable disorder. Since the characteristic electrophysiologic finding in patients with RBD is the increased electromyographic tone during REM sleep/Stage R, simultaneous video/polysomnography recording is essential for diagnosing this parasomnia. Moreover, several neurophysiological techniques have been used to improve our knowledge and understanding of this troubling sleep disorder. We reviewed the most important studies employing quantitative electroencephalography, event-related potentials, transcranial magnetic stimulation, brainstem reflexes and cortico-muscular coherence analysis. All these neurophysiological techniques have proven to provide a valuable tool to gain insight into the pathophysiological mechanisms underlying RBD. The review concludes with a brief discussion on the possible future implications for improving therapeutic approaches.
Find related publications in this database (using NLM MeSH Indexing): Humans -; Neurophysiological Monitoring - methods; REM Sleep Behavior Disorder - physiopathology
Find related publications in this database (Keywords): Rapid eye movement (REM) sleep behavior disorder Polysomnography; Lectroencephalography; Event-related potentials; Transcranial magnetic stimulation; Brainstem reflexes; Cortico-muscular coherence