Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Becker, JC; Andersen, MH; Schrama, D; Thor Straten, P.
Immune-suppressive properties of the tumor microenvironment.
Cancer Immunol Immunother. 2013; 62(7):1137-1148
Doi: 10.1007/s00262-013-1434-6
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PubMed
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- Leading authors Med Uni Graz
- Becker Jürgen Christian
- Co-authors Med Uni Graz
- Schrama David
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- Abstract:
- Solid tumors are more than an accumulation of cancer cells. Indeed, cancerous cells create a permissive microenvironment by exploiting non-transformed host cells. Thus, solid tumors rather resemble abnormal organs composed of the cancerous cells itself and the stroma providing the supportive framework. The stroma can be divided into the extracellular matrix consisting of proteoglycans, hyaluronic acid, and fibrous proteins, as well as stromal cells including mesenchymal and immune cells; moreover, it contains various peptide factors and metabolites. Here, we will focus on immune-modulating capacities of the tumor microenvironment.
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