Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Seidel, G; Werner, C; Weger, M; Steinbrugger, I; Haas, A.
Combination treatment of photodynamic therapy with verteporfin and intravitreal ranibizumab in patients with retinal angiomatous proliferation.
Acta Ophthalmol. 2013; 91(6):e482-e485
Doi: 10.1111/aos.12111
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- Führende Autor*innen der Med Uni Graz
- Seidel Gerald
- Co-Autor*innen der Med Uni Graz
- Haas Anton
- Steinbrugger Iris
- Weger Martin
- Werner Christoph
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- Abstract:
- Purpose: To investigate the efficacy and safety of initial photodynamic therapy (PDT) with a ranibizumab loading dose of three monthly intravitreal injections and a subsequent PRN ranibizumab regimen in the treatment of retinal angiomatous proliferation (RAP). Methods: In this 12-month prospective case series, 15 patients underwent PDT followed by 3 intravitreal ranibizumab injections at monthly intervals. At monthly follow-up examinations, further single ranibizumab injections were given in case of any intra- or subretinal fluid on optical coherence tomography (OCT), visual loss 5 letters or signs of activity on fluorescein or indocyanine green angiography. Results: Best-corrected visual acuity (BCVA) improved from 58.1 +/- 13.2 at baseline by 9.2 letters (SD +/- 8.5; p=0.004) at 6months and by 8.7 letters (SD +/- 11.4; p=0.017) at 12months. Neither at 6 nor at 12months, any patient had lost 15 letters. The mean number of injections per patient was 4.8 (SD +/- 1.4) in the first year of therapy after PDT. The average time to first retreatment was 3.7months (range 1-7months). No serious adverse events, such as endophthalmitis or retinal detachment, were noted. Conclusion: PDT with 3 ranibizumab loading injections and subsequent ranibizumab as needed resulted in a significant gain of 8.7 +/- 11.4 letters at month 12. This regimen is safe and efficacious, but even in a population of mostly early stages of RAP, retreatment rates remained high.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Angiogenesis Inhibitors - therapeutic use
- Antibodies, Monoclonal, Humanized - therapeutic use
- Coloring Agents - diagnostic use
- Combined Modality Therapy -
- Female -
- Fluorescein Angiography -
- Humans -
- Indocyanine Green - diagnostic use
- Intravitreal Injections -
- Macular Degeneration - diagnosis
- Male -
- Photochemotherapy -
- Photosensitizing Agents - therapeutic use
- Porphyrins - therapeutic use
- Prospective Studies -
- Retinal Neovascularization - diagnosis
- Tomography, Optical Coherence -
- Vascular Endothelial Growth Factor A - antagonists & inhibitors
- Visual Acuity - physiology
- Find related publications in this database (Keywords)
- Age-related macular degeneration
- Anti-VEGF therapy
- Photodynamic therapy
- Ranibizumab
- Retinal angiomatous proliferation