Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Gizurarson, S; Huppertz, B; Osol, G; Skarphedinsson, JO; Mandala, M; Meiri, H; .
Effects of Placental Protein 13 on the Cardiovascular System in Gravid and Non-Gravid Rodents.
Fetal Diagn Ther. 2013; 33(4):257-264
Doi: 10.1159/000345964
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Huppertz Berthold
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- Abstract:
- Objectives: Here, we performed a pathophysiological examination of the vascular function of rodent in the presence of placental protein 13 (PP13) and its implication to regulate the development of preeclampsia. Methods: Single i.v. injection and prolonged in vivo exposure to PP13 via osmotic pumps were performed in gravid and non-gravid rats to examine the influence of PP13 on blood pressure and heart rate in animals. The effect of PP13 was also examined in isolated uterine and mesenteric arteries, along with the examination of placental blood supply. Results: Human PP13 has a major impact on the maternal cardiovascular system of rodents by reducing blood pressure, either at single or prolonged exposure, and causing significant vasodilatation in isolated arteries. Prolonged exposure was followed by increased elaboration and angiogenesis of the uteroplacental arteries supplying the placenta. Conclusion:This is the first study describing effects of PP13 on vasodilatation and uterine artery remodeling. The results imply that PP13 may have a physiological role in improving uteroplacental blood flow. The findings of this study make it tempting to speculate that keeping PP13 levels within a certain 'therapeutic window' during pregnancy may facilitate proper adaptation of the maternal vasculature to pregnancy. Copyright (C) 2013 S. Karger AG, Basel
- Find related publications in this database (using NLM MeSH Indexing)
- Administration, Intravenous -
- Animals -
- Blood Pressure - drug effects
- Female -
- Galectins - administration & dosage Galectins - genetics Galectins - metabolism Galectins - pharmacology
- Heart Rate - drug effects
- Humans -
- Infusions, Subcutaneous -
- Mesenteric Arteries - drug effects Mesenteric Arteries - metabolism
- Placenta - blood supply Placenta - drug effects Placenta - metabolism
- Placental Circulation - drug effects
- Pre-Eclampsia - blood Pre-Eclampsia - metabolism Pre-Eclampsia - prevention & control
- Pregnancy -
- Pregnancy Proteins - administration & dosage Pregnancy Proteins - genetics Pregnancy Proteins - metabolism Pregnancy Proteins - pharmacology
- Rats -
- Rats, Sprague-Dawley -
- Rats, Wistar -
- Recombinant Proteins - administration & dosage Recombinant Proteins - blood Recombinant Proteins - metabolism Recombinant Proteins - pharmacology
- Uterine Artery - drug effects Uterine Artery - metabolism
- Uterus - blood supply Uterus - drug effects Uterus - metabolism
- Vasodilation - drug effects
- Find related publications in this database (Keywords)
- Early pregnancy
- First trimester
- Galectins
- Placental protein 13
- Preeclampsia
- Vasodilatation