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Selected Publication:
Urlesberger, B; Zobel, G; Zenz, W; Kuttnig-Haim, M; Maurer, U; Reiterer, F; Riccabona, M; Dacar, D; Gallisti, S; Leschnik, B; Muntean, W.
Activation of the clotting system during extracorporeal membrane oxygenation in term newborn infants.
J Pediatr. 1996; 129(2):264-268
Doi: 10.1016/S0022-3476(96)70252-4
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- Leading authors Med Uni Graz
- Urlesberger Berndt
- Co-authors Med Uni Graz
- Dacar Drago
- Gallistl Siegfried
- Haim Michaela
- Leschnik Bettina
- Muntean Eugen
- Reiterer Friedrich
- Riccabona Michael
- Zenz Werner
- Zobel Gerfried
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- Abstract:
- OBJECTIVES: To determine the degree of clotting activation that occurs with the usual anticoagulation regimen with systemic heparinization. METHODS: To allow a standardized comparison of the patients, this study focused on the first 48 hours of extracorporeal membrane oxygenation (ECMO) in term newborn infants. The ECMO perfusion circuit consisted of a roller pump, silicone membrane lungs, and silicone rubber tubing. Coagulation was controlled routinely by measuring prothrombin time, fibrinogen, antithrombin III, and reptilase time. Platelet counts, activated clotting time, and heparin concentration were controlled regularly. The following specific activation markers of the clotting system were measured: prothrombin activation fragment 1 + 2(F1+2), thrombin-antithrombin III complexes, and D-dimer. Measurements were done before the start of ECMO, after 5 minutes, and at hours 1, 2, 3, 4, 6, 12, 24 and 48. RESULTS: All seven term infants had excessively high levels of clotting activation markers within the first 2 hours of ECMO: F1+2, 11.6(+/- O.9) nmol/L (mean +/- SEM); thrombin-antithrombin, 920(+/- 2.2) microg/L; D-dimer, 15.522(+/- 3.689) ng/L. During the next 46 hours of ECMO, F1+2 and thrombin-antithrombin III complexes decreased from those high values, whereas D-dimer did not. The increase of activation markers was accompanied by low fibrinogen, low platelet counts. and prolongation of reptilase time. CONCLUSIONS: These findings fit the pattern of consumptive coagulopathy during neonatal ECMO, especially in the first 24 hours.
- Find related publications in this database (using NLM MeSH Indexing)
- Anticoagulants - administration and dosage
- Antithrombin III - analysis
- Batroxobin - blood
- Blood Coagulation - blood
- Equipment Design - blood
- Extracorporeal Membrane Oxygenation - instrumentation
- Fibrin Fibrinogen Degradation Products - analysis
- Fibrinogen - analysis
- Follow-Up Studies - analysis
- Heparin - administration and dosage
- Humans - administration and dosage
- Infant, Newborn - blood
- Intubation - instrumentation
- Membranes, Artificial - instrumentation
- Peptide Fragments - analysis
- Peptide Hydrolases - analysis
- Platelet Count - analysis
- Prothrombin - analysis
- Prothrombin Time - analysis
- Silicone Elastomers - analysis
- Silicones - analysis
- Whole Blood Coagulation Time - analysis