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Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Kau, T; Taschwer, M; Deutschmann, H; Schönfelder, M; Weber, JR; Hausegger, KA.
The "central vein sign": is there a place for susceptibility weighted imaging in possible multiple sclerosis?
Eur Radiol. 2013; 23(7):1956-1962
Doi: 10.1007/s00330-013-2791-4
Web of Science
PubMed
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- Leading authors Med Uni Graz
- Kau Thomas
- Co-authors Med Uni Graz
- Deutschmann Hannes
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- Abstract:
- Susceptibility weighted imaging (SWI) may have the potential to depict the perivenous extent of white matter lesions (WMLs) in multiple sclerosis (MS). We aimed to assess the discriminatory value of the "central vein sign" (CVS). In a 3-T magnetic resonance imaging (MRI) study, 28 WMLs in 14 patients with at least one circumscribed lesion >5 mm and not more than eight non-confluent lesions >3 mm were prospectively included. Only WMLs in FLAIR images with a maximum diameter of >5 mm were correlated to their SWI equivalent for CVS evaluation. Five patients fulfilled the revised McDonald criteria for MS and nine patients were given alternative diagnoses. Nineteen MS-WMLs and nine non-MS-WMLs >5 mm were detected. Consensus reading found a central vein in 16 out of 19 MS-WMLs (84 %) and in one out of nine non-MS-WMLs (11 %), respectively. The CVS proved to be a highly significant discriminator (P < 0.001) between MS-WMLs and non-MS-WMLs with a sensitivity, specificity, positive and negative predictive value and accuracy of 84 %, 89 %, 94 %, 73 % and 86 %, respectively. Inter-rater agreement was good (κ = 0.77). Even though the CVS is not exclusively found in MS-WMLs, SWI may be a useful adjunct in patients with possible MS. • MRI continues to yield further information concerning MS lesions. • SWI adds diagnostic information in patients with possible MS. • The "central vein sign" was predominantly seen in MS lesions. • The "central vein sign" helps discriminate between MS and non-MS lesions.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Brain - pathology
- Child -
- Child, Preschool -
- Female -
- Humans -
- Image Processing, Computer-Assisted - methods
- Magnetic Resonance Imaging - methods
- Male -
- Middle Aged -
- Multiple Sclerosis - diagnosis
- Multiple Sclerosis - pathology
- Nerve Fibers, Myelinated - pathology
- Observer Variation -
- Predictive Value of Tests -
- Prospective Studies -
- Reproducibility of Results -
- Veins - pathology
- Young Adult -
- Find related publications in this database (Keywords)
- Multiple sclerosis
- White matter lesions
- Central vein sign
- Magnetic resonance imaging
- Susceptibility weighted imaging