Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Kniepeiss, D; Wagner, D; Wasler, A; Tscheliessnigg, KH; Renner, W.
The role of CYP2C8 genotypes in dose requirement and levels of everolimus after heart transplantation.
Wien Klin Wochenschr. 2013; 125(13-14):393-395
Doi: 10.1007/s00508-013-0387-2
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Kniepeiss Daniela
- Co-Autor*innen der Med Uni Graz
- Renner Wilfried
- Tscheliessnigg Karlheinz
- Wagner Doris
- Wasler Andrae
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- Abstract:
- Everolimus is an immunosuppressive drug metabolized by enzymes of the CYP family. A common variant of the CYP2C8 gene, CYP2C8*3, results in strongly decreased CYP2C8 activity, but its role for the pharmacogenetics of everolimus remains unclear. Aim of the present study was to examine the role of CYP2C8 variants in everolimus dose and drug levels after heart transplantation. The present study comprised 30 patients with everolimus based maintenance therapy after heart transplantation. CYP2C8 genotypes were determined and correlated with clinical data. In all, 21 subjects carried the CYP2C8 *1/*1 genotype and 9 subjects carried the CYP2C8 *1/*3 genotype. Neither everolimus dose nor everolimus levels were associated with CYP2C8 genotype at any point of time (p < 0.05). During follow-up, graft rejection reactions were observed in two patients and infections were observed in seven patients. In one patient, type 2 diabetes was diagnosed during follow-up. None of these adverse events were significantly associated with CYP2C8 genotypes. We conclude that in adult patients after heart transplantation, CYP2C8 genotypes are not associated with dose requirements or levels of everolimus.
- Find related publications in this database (using NLM MeSH Indexing)
- Aryl Hydrocarbon Hydroxylases - blood
- Dose-Response Relationship, Drug -
- Female -
- Genotype -
- Graft Rejection - blood
- Heart Transplantation - adverse effects
- Humans -
- Immunosuppressive Agents - adverse effects
- Male -
- Pharmacogenetics - methods
- Sirolimus - analogs & derivatives
- Treatment Outcome -
- Find related publications in this database (Keywords)
- Heart transplantation
- Immunosuppression
- Genotypes