Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Coraça-Huber, DC; Putzer, D; Fille, M; Hausdorfer, J; Nogler, M; Kühn, KD.
Gentamicin palmitate as a new antibiotic formulation for mixing with bone tissue and local release.
Cell Tissue Bank. 2014; 15(1):139-144
Doi: 10.1007/s10561-013-9384-y
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Kühn Klaus-Dieter
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- Abstract:
- During surgery with bone grafting, the impaction of bone tissue creates an avascular area where local circulation is disrupted. If infections arise, they may prevent systemically administered antibiotics from reaching the infected bone. In this study we evaluated gentamicin palmitate (GP) mixed with gentamicin sulfate (GS) as a coating for bone chips (BCh). The efficacy of the coated BCh was measured by gentamicin base release tests using B. subtilis, S. epidermidis and S. aureus. Gentamicin base release was evaluated in phosphate-buffered saline for up to 7 days using B. subtilis bioassay. Antimicrobial efficacy was tested with S. aureus and S. epidermidis. A significant difference on the release of gentamicin base between GS and GS + GP was observed. S. epidermidis are significantly more susceptible to GS + GP and GS than S. aureus. BCh can act as gentamicin carriers and showed efficacy against S. aureus and S. epidermidis.
- Find related publications in this database (using NLM MeSH Indexing)
- Allografts -
- Anti-Bacterial Agents - pharmacology
- Antibiotic Prophylaxis - methods
- Bacillus subtilis - drug effects
- Bone Transplantation - methods
- Bone and Bones - microbiology
- Disinfection -
- Gentamicins - pharmacology
- Gram-Positive Bacterial Infections - drug therapy
- Gram-Positive Bacterial Infections - prevention & control
- Humans -
- Microbial Sensitivity Tests -
- Staphylococcal Infections - drug therapy
- Staphylococcal Infections - prevention & control
- Staphylococcus aureus - drug effects
- Staphylococcus epidermidis - drug effects
- Find related publications in this database (Keywords)
- Bone allografts
- Anti-infective coating
- Gentamicin palmitate
- Bacillus subtilis
- Staphylococcus aureus
- Staphylococcus epidermidis