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SHR Neuro Cancer Cardio Lipid Metab Microb

Schnedl, C; Pieber, TR; Amrein, K.
Vitamin D intervention trials in critical illness.
Inflamm Allergy Drug Targets. 2013; 12(4):282-287 Doi: 10.2174/18715281113129990043
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Leading authors Med Uni Graz: Schnedl Christian
Co-authors Med Uni Graz: Amrein Karin; Pieber Thomas
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Abstract:: Vitamin D deficiency is common in critically ill patients and has been associated with adverse outcomes. Although many interesting observational studies have been published, only four small randomized controlled trials have been conducted in this vulnerable population. Endpoints included bone turnover, inflammatory markers and safety/efficacy issues. However, all of these trials were underpowered to detect clinically relevant endpoints due to their small sample size. Therefore, future studies focusing on morbidity and mortality endpoints are necessary in order to clarify whether vitamin D deficiency is only a surrogate marker for disease severity or whether treatment with sufficiently large doses of vitamin D may improve patient outcome in an intensive care setting.
Find related publications in this database (using NLM MeSH Indexing): Critical Illness - mortality; Humans -; Intensive Care -; Randomized Controlled Trials as Topic -; Vitamin D - administration & dosage; Vitamin D Deficiency - complications