Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Lerchbaum, E; Schwetz, V; Pilz, S; Boehm, BO; März, W.
Association of bone turnover markers with mortality in women referred to coronary angiography: the Ludwigshafen Risk and Cardiovascular Health (LURIC) study.
Osteoporos Int. 2014; 25(2):455-465
Doi: 10.1007/s00198-013-2411-9
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Lerchbaum Elisabeth
- Co-Autor*innen der Med Uni Graz
- März Winfried
- Pilz Stefan
- Theiler-Schwetz Verena
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- Abstract:
- We examined the association of fatal events with beta-crosslaps (β-CTX) and osteocalcin (OC) concentrations in women. We observed an independent association of β-CTX and OC concentrations with fatal events in women at high to intermediate cardiovascular risk. There is some evidence suggesting an association of β-CTX and OC with fatal events in men and frail elderly subjects. We aimed to examine the association of fatal events with β-CTX and OC in women. We measured β-CTX and OC in 986 women aged 65 (58-72) years referred to coronary angiography. Compared to the first β-CTX quartile, the crude hazard ratios (HRs) for all-cause and cardiovascular mortality in the highest β-CTX quartile were 2.50 (1.65-3.81) and 3.28 (1.82-5.91), respectively. In multivariate adjusted models, HRs for all-cause and cardiovascular mortality in the highest β-CTX quartile were 1.72 (1.09-2.70) and 2.31 (1.24-4.32), respectively. The lowest 25-hydroxyvitamin D [25(OH)D] quartile was significantly associated with increased risk of all-cause and cardiovascular mortality in multivariate adjusted models. In those models, the highest β-CTX quartile was associated with an increased risk of all-cause and cardiovascular mortality. For OC concentrations, we found a reverse J-shaped association with noncardiovascular mortality. Using the first quartile as reference, crude and multivariate adjusted HRs for noncardiovascular mortality in the second and third OC quartile were 0.41 (0.19-0.90) [multivariate: 0.40 (0.18-0.88)] and 0.51 (0.25-1.06) [multivariate: 0.43 (0.20-0.94)], respectively. The lowest 25(OH)D quartile was associated with a trend towards increased risk of noncardiovascular mortality in multivariate analysis. In that analysis, OC quartile 2 and 3 were significantly associated with lower risk of noncardiovascular mortality. We observed an independent association of high β-CTX with all-cause and cardiovascular mortality and a reverse J-shaped association of OC with noncardiovascular mortality.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Biomarkers - blood
- Bone Remodeling - physiology
- Cardiovascular Diseases - blood
- Cardiovascular Diseases - diagnostic imaging
- Cardiovascular Diseases - mortality
- Cardiovascular Diseases - physiopathology
- Collagen - blood
- Coronary Angiography -
- Female -
- Follow-Up Studies -
- Germany - epidemiology
- Humans -
- Male -
- Middle Aged -
- Osteocalcin - blood
- Peptide Fragments - blood
- Prospective Studies -
- Find related publications in this database (Keywords)
- Beta-crosslaps
- Bone turnover
- Cardiovascular disease
- Mortality
- Osteocalcin