Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Weisbecker, H; Viertler, C; Pierce, DM; Holzapfel, GA.
The role of elastin and collagen in the softening behavior of the human thoracic aortic media.
J Biomech. 2013; 46(11):1859-1865
Doi: 10.1016/j.jbiomech.2013.04.025
Web of Science
PubMed
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- Co-authors Med Uni Graz
- Viertler Christian
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- Abstract:
- In a previous study we were able to accurately fit experimental data on arterial tissues at supra-physiological loads using a material model that accounts for softening/damage only in the portion of the model associated with the collagen fibers (Weisbecker et al., 2012). Naturally, this result leads to the hypothesis that the softening behavior is related only to the collagen fibers, and not to the matrix material. In this study we test this hypothesis by conducting uniaxial extension tests on elastase and collagenase treated tissues and on untreated control specimens from the media of human thoracic aortas. We relate structural changes in the tissue after enzyme treatment to changes in the corresponding mechanical behavior. Collagenase treated tissue does not exhibit any softening behavior under quasi-static cyclic loading, a result supporting our hypothesis. Conversely, elastase treated tissue exhibits continuous softening under the same loading conditions, indicating that the integrity of the tissue is destroyed upon removal of the elastin. Finally, we fit isotropic and anisotropic constitutive models to the mechanical response of the collagenase treated arterial tissue, while our anisotropic model better approximates the response of collagenase treated arterial tissues, we show that an isotropic matrix model is sufficient to accurately reproduce the mechanical response of untreated control specimens, consistent with current practice in the literature.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Aorta, Thoracic - anatomy & histology
- Biomechanical Phenomena -
- Collagen - physiology
- Collagenases - pharmacology
- Elastin - physiology
- Female -
- Humans -
- Male -
- Middle Aged -
- Models, Cardiovascular -
- Pancreatic Elastase - pharmacology
- Tunica Media - physiology
- Find related publications in this database (Keywords)
- Human aorta
- Elastase
- Collagenase
- Constitutive modeling
- Softening
- Damage