Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Benhaim, L; Gerger, A; Bohanes, P; Paez, D; Wakatsuki, T; Yang, D; Labonte, MJ; Ning, Y; El-Khoueiry, R; Loupakis, F; Zhang, W; Laurent-Puig, P; Lenz, HJ.
Gender-specific profiling in SCN1A polymorphisms and time-to-recurrence in patients with stage II/III colorectal cancer treated with adjuvant 5-fluoruracil chemotherapy.
Pharmacogenomics J. 2014; 14(2):135-141
Doi: 10.1038/tpj.2013.21
Web of Science
PubMed
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- Co-authors Med Uni Graz
- Gerger Armin
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- Abstract:
- This study was designed to analyze the gender-related association between SCN1A polymorphisms (voltage-gated sodium channels; α-subunit) and time-to-recurrence (TTR) in patients with colorectal cancer (CRC) treated with 5-fluoruracil (5-FU)-based adjuvant chemotherapy. We enrolled from a prospective database patients with stage II and III CRC treated with adjuvant 5-FU-based chemotherapy. Genotypes for SCN1A rs3812718 and rs229877 were determined by direct DNA sequencing. One hundred twenty-seven males and 107 females were included in the study. In the univariate and multivariate analysis, the shortest TTR was associated with female patients carrying the rs3812718-TT genotype (hazard ratio (HR): 2.26 (95% confidence interval (CI): 0.89, 5.70), P=0.039) but with male patients carrying the rs3812718-CC genotype (HR: 0.49 (95% CI: 0.18, 1.38), P=0.048). For rs229877 the CT genotype was associated with a trend for shorter TTR in both gender populations. The study validated gender-dependent association between genomic SCN1A rs3812718 polymorphism and TTR in CRC patients treated with adjuvant 5-FU-based chemotherapy. This study confirms that voltage-gated Na+ channels may be a potential therapeutic target and a useful predictive biomarker before 5-FU infusion.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Aged, 80 and over -
- Chemotherapy, Adjuvant - adverse effects
- Colorectal Neoplasms - drug therapy
- Colorectal Neoplasms - genetics
- Colorectal Neoplasms - pathology
- Disease-Free Survival -
- Female -
- Fluorouracil - administration & dosage
- Fluorouracil - adverse effects
- Humans -
- Male -
- Middle Aged -
- NAV1.1 Voltage-Gated Sodium Channel - genetics
- Neoplasm Staging -
- Polymorphism, Genetic -
- Polymorphism, Single Nucleotide -
- Prognosis -
- Sex Characteristics -
- Find related publications in this database (Keywords)
- colorectal cancer
- gender
- polymorphism
- SCN1A
- VGSC
- voltage-gated sodium channels