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SHR Neuro Cancer Cardio Lipid Metab Microb

Pedersen, IH; Willerslev-Olsen, A; Vetter-Kauczok, C; Krejsgaard, T; Lauenborg, B; Kopp, KL; Geisler, C; Bonefeld, CM; Zhang, Q; Wasik, MA; Dabelsteen, S; Woetmann, A; Becker, JC; Odum, N; .
Vascular endothelial growth factor receptor-3 expression in mycosis fungoides.
LEUK LYMPHOMA. 2013; 54(4): 819-826. Doi: 10.3109/10428194.2012.726720
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Co-authors Med Uni Graz: Becker Jürgen Christian
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Abstract:: Here, we have studied vascular endothelial growth factor receptor-3 (VEGFR-3) expression in mycosis fungoides (MF), the most common type of cutaneous T-cell lymphoma (CTCL). Immunohistochemistry revealed that in two-thirds of 34 patients, VEGFR-3 was expressed in situ by both tumor and stromal cells irrespective of the disease stage. The natural VEGFR-3 ligand, VEGF-C, partially protected malignant T-cell lines from growth inhibition by the histone deacetylase inhibitor, suberoylanilide hydroxamic acid (SAHA). Whereas the malignant T cells did not produce VEGF-C in vitro, its expression was induced during tumor formation in vivo in a xenograft mouse model of MF. In conclusion, malignant and stromal cells express high levels of VEGFR-3 in all stages of MF. Moreover, malignant T cells trigger enhanced VEGF-C expression in fibroblasts, suggesting that cross-talk between tumor and stromal cells plays a role in lymphangiogenesis and possibly disease progression.
Find related publications in this database (using NLM MeSH Indexing): Animals -; Cell Line, Tumor -; Disease Models, Animal -; Gene Expression -; Humans -; Mice -; Mycosis Fungoides - genetics; RNA, Messenger - genetics; Skin Neoplasms - genetics; Transplantation, Heterologous -; Vascular Endothelial Growth Factor C - genetics; Vascular Endothelial Growth Factor Receptor-3 - genetics
Find related publications in this database (Keywords): Angiogenesis; VEGF; VEGF-R; VEGFR-3; CTCL