Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Pedersen, IH; Willerslev-Olsen, A; Vetter-Kauczok, C; Krejsgaard, T; Lauenborg, B; Kopp, KL; Geisler, C; Bonefeld, CM; Zhang, Q; Wasik, MA; Dabelsteen, S; Woetmann, A; Becker, JC; Odum, N; .
Vascular endothelial growth factor receptor-3 expression in mycosis fungoides.
LEUK LYMPHOMA. 2013; 54(4): 819-826.
Doi: 10.3109/10428194.2012.726720
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Becker Jürgen Christian
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- Abstract:
- Here, we have studied vascular endothelial growth factor receptor-3 (VEGFR-3) expression in mycosis fungoides (MF), the most common type of cutaneous T-cell lymphoma (CTCL). Immunohistochemistry revealed that in two-thirds of 34 patients, VEGFR-3 was expressed in situ by both tumor and stromal cells irrespective of the disease stage. The natural VEGFR-3 ligand, VEGF-C, partially protected malignant T-cell lines from growth inhibition by the histone deacetylase inhibitor, suberoylanilide hydroxamic acid (SAHA). Whereas the malignant T cells did not produce VEGF-C in vitro, its expression was induced during tumor formation in vivo in a xenograft mouse model of MF. In conclusion, malignant and stromal cells express high levels of VEGFR-3 in all stages of MF. Moreover, malignant T cells trigger enhanced VEGF-C expression in fibroblasts, suggesting that cross-talk between tumor and stromal cells plays a role in lymphangiogenesis and possibly disease progression.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Cell Line, Tumor -
- Disease Models, Animal -
- Gene Expression -
- Humans -
- Mice -
- Mycosis Fungoides - genetics
- RNA, Messenger - genetics
- Skin Neoplasms - genetics
- Transplantation, Heterologous -
- Vascular Endothelial Growth Factor C - genetics
- Vascular Endothelial Growth Factor Receptor-3 - genetics
- Find related publications in this database (Keywords)
- Angiogenesis
- VEGF
- VEGF-R
- VEGFR-3
- CTCL