Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Halilbasic, E; Baghdasaryan, A; Trauner, M.
Nuclear receptors as drug targets in cholestatic liver diseases.
Clin Liver Dis. 2013; 17(2):161-189
Doi: 10.1016/j.cld.2012.12.001
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- Leading authors Med Uni Graz
- Halilbasic Emina
- Trauner Michael
- Co-authors Med Uni Graz
- Baghdasaryan Anna
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- Abstract:
- Cholestatic liver diseases encompass a wide spectrum of disorders with different causes, resulting in impaired bile flow and accumulation of bile acids and other potentially hepatotoxic cholephils. The understanding of the molecular mechanisms of bile formation and cholestasis has recently improved significantly through new insights into nuclear receptor (patho)biology. Nuclear receptors are ligand-activated transcription factors, which act as central players in the regulation of genes responsible for elimination and detoxification of biliary constituents accumulating in cholestasis. They also control other pathophysiologic processes such as inflammation, fibrogenesis, and carcinogenesis involved in the pathogenesis and disease progression of cholestasis liver diseases. Copyright © 2013 Elsevier Inc. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Bile Acids and Salts - biosynthesis
- Cholagogues and Choleretics - therapeutic use
- Cholestasis - drug therapy Cholestasis - genetics Cholestasis - metabolism
- Homeostasis - drug effects
- Humans -
- Ligands -
- Peroxisome Proliferator-Activated Receptors - metabolism
- Receptors, Calcitriol - genetics Receptors, Calcitriol - metabolism
- Receptors, Cytoplasmic and Nuclear - agonists Receptors, Cytoplasmic and Nuclear - genetics Receptors, Cytoplasmic and Nuclear - metabolism
- Receptors, Glucocorticoid - metabolism
- Receptors, Steroid - genetics Receptors, Steroid - metabolism
- Signal Transduction - drug effects Signal Transduction - genetics
- Ursodeoxycholic Acid - therapeutic use
- Find related publications in this database (Keywords)
- Cholestatic liver disease
- Nuclear receptors
- Cholestasis
- Bile acids