Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Egger, G; Allmayer, T; Iberer, F; Tscheliessnigg, KH; Auer, T; Wasler, A; Petutschnigg, B.
Impaired Polymorphonuclear Leukocyte Migration as a Possible Monitor for the Risk of Septicemia in Immunosuppressed Transplant Patients
MED SCI RES 1996 24: 17-19.
Web of Science
- Führende Autor*innen der Med Uni Graz
- Egger Gerd
- Co-Autor*innen der Med Uni Graz
- Allmayer Thomas
- Auer-Schönbach Thomas
- Iberer Florian
- Petutschnigg Berthold
- Tscheliessnigg Karlheinz
- Wasler Andrae
- Altmetrics:
- Abstract:
- Due to immunosuppressive therapy, organ transplant patients suffer from an impaired host defence and are, therefore, threatened by infections. A new method that measures polymorphonuclear leucocyte (PMN) migration in whole blood was used for the estimation of an infection risk. Spontaneous migration of PMNs assessed by their percentage in whole blood migrating into a membrane filter was markedly reduced in immunosuppressed orthotopic heart transplantation patients who later developed septicaemia. The PMN blood counts of these patients were within the normal range and are not therefore a useful indicator of reduced host resistance to pathogens. Blood PMN functional tests promise to be a better marker for determining immunodeficiency caused by over-immunosuppression.
- Find related publications in this database (Keywords)
- Polymorphonuclear Leukocyte
- Neutrophils
- Migration
- Sepsis
- Septicemia
- Heart
- Transplantation
- Immunosuppression