Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Bodenlenz, M; Aigner, B; Dragatin, C; Liebenberger, L; Zahiragic, S; Höfferer, C; Birngruber, T; Priedl, J; Feichtner, F; Schaupp, L; Korsatko, S; Ratzer, M; Magnes, C; Pieber, TR; Sinner, F.
Clinical applicability of dOFM devices for dermal sampling.
Skin Res Technol. 2013; 19(4):474-483
Doi: 10.1111/srt.12071
Web of Science
PubMed
FullText
FullText_MUG
- Leading authors Med Uni Graz
- Sinner Frank Michael
- Weiss Manfred
- Co-authors Med Uni Graz
- Birngruber Thomas
- Feichtner Franz
- Jasarevic Samra
- Korsatko Stefan
- Pieber Thomas
- Sadoghi Birgit
- Schaupp Lukas
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- Abstract:
- Sampling the dermal interstitial fluid (ISF) allows the pharmacokinetics and pharmacodynamics of dermatological drugs to be studied directly at their site of action. Dermal open-flow microperfusion (dOFM) is a recently developed technique that can provide minimally invasive, continuous, membrane-free (thus unfiltered) access to the dermal ISF. Herein, we evaluate the clinical applicability and reliability of novel wearable dOFM devices in a clinical setting. Physicians inserted 141 membrane-free dOFM probes into the dermis of 17 healthy and psoriatic volunteers and sampled dermal ISF for 25 h by using wearable push-pull pumps. The tolerability, applicability, reproducibility, and reliability of multiple insertions and 25 h continuous sampling was assessed by pain scoring, physician feedback, ultrasound probe depth measurements, and 25 h-drift and variability of the sodium relative recovery. Insertion pain was moderate and decreased with each additional probe. Probe insertion was precise, although slightly deeper in lesional skin. The wearable push-pull pump enabled uninterrupted ISF sampling over 25 h with low variability. The relative recovery was drift-free and highly reproducible. dOFM sampling devices are tolerable and reliable for prolonged continuous dermal sampling in a multiprobe clinical setting. These devices should enable the study of a wide range of drugs and their biomarkers in the skin. © 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
- Find related publications in this database (using NLM MeSH Indexing)
- Administration, Cutaneous -
- Adult -
- Biomarkers - metabolism
- Dermatologic Agents - administration & dosage
- Dermatologic Agents - pharmacokinetics
- Dermis - drug effects
- Dermis - metabolism
- Extracellular Fluid - metabolism
- Female -
- Humans -
- Infusion Pumps -
- Male -
- Microdialysis - instrumentation
- Microdialysis - methods
- Microdialysis - standards
- Middle Aged -
- Needles -
- Perfusion - instrumentation
- Perfusion - methods
- Perfusion - standards
- Reproducibility of Results -
- Sodium - metabolism
- Young Adult -
- Find related publications in this database (Keywords)
- open-flow microperfusion
- in vivo
- human
- interstitial fluid
- cutaneous
- pharmacokinetics
- pharmacodynamics
- tolerability
- push-pull
- bioequivalence