Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Haas, HS; Pfragner, R; Tabrizi-Wizsy, NG; Rohrer, K; Lueftenegger, I; Horwath, C; Allard, N; Rinner, B; Sadjak, A.
The influence of glutamate receptors on proliferation and metabolic cell activity of neuroendocrine tumors.
Anticancer Res. 2013; 33(4): 1267-1272.
Web of Science
PubMed
- Führende Autor*innen der Med Uni Graz
- Haas Helga Susanne
- Co-Autor*innen der Med Uni Graz
- Ghaffari Tabrizi-Wizsy Nassim
- Horwath Charlotte
- Meier-Allard Nathalie
- Pfragner Roswitha
- Rinner Beate
- Sadjak Anton
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- Abstract:
- Neuroendocrine tumors are relatively insensitive to radiation therapy, as well as chemotherapy. Thus, new approaches for alternative therapies are needed. We found that glutamate receptor antagonists are capable of suppressing tumor growth and cell activity of different peripheral malignancies. In the present article we review scientific literature in this field of science. Subtype-specific, non-competitive, metabotropic glutamate receptor-1 antagonists differently suppressed the growth and metabolic cell activity of one human medullary thyroid carcinoma cell line, as well as of four different human midgut neuroendocrine tumor cell lines. Furthermore, PCR analyses revealed that this subtype of glutamate receptor is expressed in these cell lines. These first results indicate that specific metabotropic glutamate receptor antagonists suppress the proliferation and cell activity of neuroendocrine tumor cells, which makes them possible targets in cancer therapy.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Antineoplastic Agents - therapeutic use
- Cell Proliferation - drug effects
- Humans -
- Neuroendocrine Tumors - drug therapy Neuroendocrine Tumors - metabolism Neuroendocrine Tumors - pathology
- Receptors, Glutamate - chemistry Receptors, Glutamate - metabolism
- Find related publications in this database (Keywords)
- Metabotropic glutamate receptors
- cell proliferation
- tumor biology
- neuroendocrine tumors
- alternative therapy
- review