Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Mangge, H; Summers, KL; Meinitzer, A; Zelzer, S; Almer, G; Prassl, R; Schnedl, WJ; Reininghaus, E; Paulmichl, K; Weghuber, D; Fuchs, D.
Obesity-related dysregulation of the tryptophan-kynurenine metabolism: role of age and parameters of the metabolic syndrome.
Obesity (Silver Spring). 2014; 22(1):195-201
Doi: 10.1002/oby.20491
[OPEN ACCESS]
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Mangge Harald
- Co-Autor*innen der Med Uni Graz
- Almer Gunter
- Meinitzer Andreas
- Prassl Ruth
- Reininghaus Eva
- Schnedl Wolfgang
- Zelzer Sieglinde
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- Obesity-related immune mediated systemic inflammation was associated with the development of the metabolic syndrome by induction of the tryptophan (TRP)-kynurenine (KYN) pathway. The study aimed to assess whether this holds true across the lifespan from juvenility to adulthood. Five hundred twenty-seven participants aged between 10 and 65 years were analyzed. Standard anthropometric measures, carotid ultrasound, and laboratory analysis including interleukin-6, ultra-sensitive C-reactive protein, lipids, glucose metabolism, neopterin, TRP, KYN levels, and the KYN/TRP ratio were performed. Overweight/obese (ow/ob) adults had significantly increased KYN serum levels and a significantly increased KYN/TRP ratio. In sharp contrast, ow/ob juvenile males aged ≤18 years showed decreased, females similar KYN and KYN/TRP ratio in comparison to their control counterparts. Also, adult ow/ob subjects with metabolic syndrome showed markedly increased KYN/TRP ratios contrary to decreased KYN/TRP ratios in ow/ob juveniles. Abdominal fat content, characterized by age normalized waist circumference, and not body mass index, had the strongest effect for an increase of the KYN/TRP ratio in adults. TRP metabolism and obesity-related immune mediated inflammation differs markedly between juveniles and adults. While childhood obesity seems to be dominated by a Th2-driven activation, an accelerated production of Th1-type cytokines may pave the way for later atherosclerotic endpoints. Copyright © 2013 The Obesity Society.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Age Factors -
- Aged -
- C-Reactive Protein - metabolism
- Child -
- Female -
- Humans -
- Interleukin-6 - blood
- Kynurenine - blood
- Male -
- Metabolic Syndrome - blood
- Metabolic Syndrome - etiology
- Metabolic Syndrome - physiopathology
- Middle Aged -
- Neopterin - metabolism
- Obesity - blood
- Obesity - complications
- Obesity - physiopathology
- Observational Studies as Topic -
- Tryptophan - blood
- Young Adult -