Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Großekatthöfer, M; Güclü, ED; Lawitschka, A; Matthes-Martin, S; Mann, G; Minkov, M; Peters, C; Seidel, MG.
Ferritin concentrations correlate to outcome of hematopoietic stem cell transplantation but do not serve as biomarker of graft-versus-host disease.
Ann Hematol. 2013; 92(8):1121-1128
Doi: 10.1007/s00277-013-1737-x
Web of Science
PubMed
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- Seidel Markus
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- Abstract:
- Clinical presentation and laboratory data are often too unspecific to distinguish the onset or activity of graft-versus-host disease (GvHD) from infections or toxicity. Antigen-presenting cells such as monocytes/macrophages and dendritic cells are involved in GvHD pathogenesis after allogeneic hematopoietic stem cell transplantation (HSCT). To test whether ferritin, an iron storage marker and macrophage activation-linked acute-phase protein, represents a candidate biomarker for acute or chronic GvHD in pediatric HSCT, we retrospectively evaluated a 2-year follow-up data from 131 eligible consecutive patients with different malignant and nonmalignant diseases who underwent allogeneic HSCT. Thirteen patients (10 %) suffered from acute GvHD II-IV°, 18 (14 %) had limited, and 14 (11 %) had extensive chronic GvHD. In extension of previous studies in adults investigating pre-transplant ferritin, our data show that post-HSCT hyperferritinemia (analyzed on days 0, +30, +60, +100, +180, +360, and +720) was significantly associated with decreased long-term survival (p < 0.001-0.03) in children and adolescents. Increased ferritin concentrations were associated with number and timing of red blood cell transfusions and toxic or infectious multi-organ failure but did not show significant differences between patients without GvHD and with acute grades II-IV, limited, or extensive chronic GvHD. Thus, our data do not identify ferritin as specifically GvHD-linked biomarker; however, they support the prognostic value of ferritin levels for outcome after HSCT in children.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Biological Markers -
- Child -
- Child, Preschool -
- Erythrocyte Transfusion - utilization
- Female -
- Ferritins - analysis
- Follow-Up Studies -
- Graft vs Host Disease - blood
- Hematologic Diseases - surgery
- Hematologic Neoplasms - surgery
- Hematopoietic Stem Cell Transplantation - adverse effects
- Humans -
- Immunosuppression -
- Infant -
- Infant, Newborn -
- Lymphohistiocytosis, Hemophagocytic - epidemiology
- Male -
- Multiple Organ Failure - epidemiology
- Postoperative Complications - epidemiology
- Predictive Value of Tests -
- Retrospective Studies -
- Transplantation Conditioning -
- Transplantation, Homologous -
- Treatment Outcome -
- Young Adult -
- Find related publications in this database (Keywords)
- Graft-versus-host disease
- Ferritin
- Allogeneic hematopoietic stem cell transplantation
- Iron overload
- Biomarker
- Post-transplant hemophagocytic lymphohistiocytosis
- Hemophagocytic syndrome