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Schughart, K; Libert, C; SYSGENET consortium; Kas, MJ.
Controlling complexity: the clinical relevance of mouse complex genetics.
Eur J Hum Genet. 2013; 21(11):1191-1196
Doi: 10.1038/ejhg.2013.79
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Fröhlich Leopold F.
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- Abstract:
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Experimental animal models are essential to obtain basic knowledge of the underlying biological mechanisms in human diseases. Here, we review major contributions to biomedical research and discoveries that were obtained in the mouse model by using forward genetics approaches and that provided key insights into the biology of human diseases and paved the way for the development of novel therapeutic approaches.
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Animals -
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Biomedical Research -
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Humans -
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Mice -
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Models, Animal -
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Reverse Genetics -
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Mouse model
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forward genetics
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review