Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Steinwender, G; Lindner, E; Weger, M; Plainer, S; Renner, W; Ardjomand, N; El-Shabrawi, Y.
Association between polymorphism of the vitamin D metabolism gene CYP27B1 and HLA-B27-associated uveitis. Is a state of relative immunodeficiency pathogenic in HLA B27-positive uveitis?
PLoS One. 2013; 8(4):e62244-e62244
Doi: 10.1371/journal.pone.0062244
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- Führende Autor*innen der Med Uni Graz
- El-Shabrawi Yosuf
- Steinwender Gernot
- Co-Autor*innen der Med Uni Graz
- Ardjomand Navid
- Lindner Ewald
- Renner Wilfried
- Weger Martin
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- Abstract:
- Polymorphisms of the vitamin D metabolism gene CYP27B1 showed associations with multiple autoimmune diseases. The aim of this study was to investigate a possible association between the rs703842 A>G polymorphism of the CYP27B1 gene and HLA-B27-associated uveitis. One hundred fifty-nine patients with HLA-B27-associated uveitis, 138 HLA-B27-negative controls and 100 HLA-B27-positive controls were recruited for this retrospective case-control study. Main outcome parameters were genotype distribution and allelic frequencies determined by polymerase chain reaction. Carriers of the rs703842G allele were found significantly more often in patients with HLA-B27-associated uveitis than in HLA-B27-positive controls (p = 0.03). Between patients and HLA-B27-negative controls no significant difference in the genotype distribution of the rs703842 A>G polymorphism was found (p = 0.97). Our data suggest that the rs703842 A>G polymorphism may play a role in HLA-B27-associated uveitis.
- Find related publications in this database (using NLM MeSH Indexing)
- 25-Hydroxyvitamin D3 1-alpha-Hydroxylase - genetics
- Adult -
- Case-Control Studies -
- Demography -
- Female -
- Genetic Association Studies -
- Genetic Predisposition to Disease -
- HLA-B27 Antigen - genetics
- Humans -
- Male -
- Polymorphism, Single Nucleotide - genetics
- Uveitis - enzymology
- Uveitis - genetics
- Uveitis - immunology
- Vitamin D - metabolism