Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Omicron Hartaigh, B; Thomas, GN; Bosch, JA; Hemming, K; Pilz, S; Loerbroks, A; Kleber, ME; Grammer, TB; Fischer, JE; Silbernagel, G; Tomaschitz, A; März, W.
Evaluation of 9 biomarkers for predicting 10-year cardiovascular risk in patients undergoing coronary angiography: findings from the LUdwigshafen RIsk and Cardiovascular Health (LURIC) study.
Int J Cardiol. 2013; 168(3):2609-2615
Doi: 10.1016/j.ijcard.2013.03.043
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- Co-Autor*innen der Med Uni Graz
- März Winfried
- Pilz Stefan
- Silbernagel Günther
- Tomaschitz Andreas
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- Abstract:
- Conventional factors do not fully explain the distribution of cardiovascular outcomes. Biomarkers are known to participate in well-established pathways associated with cardiovascular disease, and may therefore provide further information over and above conventional risk factors. This study sought to determine whether individual and/or combined assessment of 9 biomarkers improved discrimination, calibration and reclassification of cardiovascular mortality. 3267 patients (2283 men), aged 18-95 years, at intermediate-to-high-risk of cardiovascular disease were followed in this prospective cohort study. Conventional risk factors and biomarkers were included based on forward and backward Cox proportional stepwise selection models. During 10-years of follow-up, 546 fatal cardiovascular events occurred. Four biomarkers (interleukin-6, neutrophils, von Willebrand factor, and 25-hydroxyvitamin D) were retained during stepwise selection procedures for subsequent analyses. Simultaneous inclusion of these biomarkers significantly improved discrimination as measured by the C-index (0.78, P = 0.0001), and integrated discrimination improvement (0.0219, P<0.0001). Collectively, these biomarkers improved net reclassification for cardiovascular death by 10.6% (P<0.0001) when added to the conventional risk model. In terms of adverse cardiovascular prognosis, a biomarker panel consisting of interleukin-6, neutrophils, von Willebrand factor, and 25-hydroxyvitamin D offered significant incremental value beyond that conveyed by simple conventional risk factors. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Aged -
- Aged, 80 and over -
- Biomarkers - blood
- Cardiovascular Diseases - blood Cardiovascular Diseases - mortality
- Coronary Angiography -
- Female -
- Humans -
- Male -
- Middle Aged -
- Predictive Value of Tests -
- Prospective Studies -
- Risk Assessment -
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- Find related publications in this database (Keywords)
- Cardiovascular
- Risk factor
- Biomarker
- Discrimination
- Reclassification