Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Hacker, E; Nagore, E; Cerroni, L; Woods, SL; Hayward, NK; Chapman, B; Montgomery, GW; Soyer, HP; Whiteman, DC; .
NRAS and BRAF Mutations in Cutaneous Melanoma and the Association with MC1R Genotype: Findings from Spanish and Austrian Populations.
J INVEST DERMATOL. 2013; 133(4): 1027-1033.
Doi: 10.1038/jid.2012.385
[OPEN ACCESS]
Web of Science
PubMed
FullText
FullText_MUG
- Co-Autor*innen der Med Uni Graz
- Cerroni Lorenzo
- Soyer Hans Peter
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- There is increasing epidemiologic and molecular evidence that cutaneous melanomas arise through multiple causal pathways. To further define the pathways to melanoma, we explored the relationship between germline and somatic mutations in a series of melanomas collected from 134 Spanish and 241 Austrian patients. Tumor samples were analyzed for melanocortin-1 receptor (MC1R) variants and mutations in the BRAF and NRAS genes. Detailed clinical data were systematically collected from patients. We found that NRAS-mutant melanomas were significantly more likely from older patients and BRAF-mutant melanomas were more frequent in melanomas from the trunk. We observed a nonsignificant association between germline MC1R status and somatic BRAF mutations in melanomas from trunk sites (odds ratio (OR) 1.8 (0.8-4.1), P=0.1), whereas we observed a significant inverse association between MC1R and BRAF for melanomas of the head and neck (OR 0.3 (0.1-0.8), P=0.02). This trend was observed in both the Spanish and Austrian populations.
- Find related publications in this database (using NLM MeSH Indexing)
- - epidemiology
- Female -
- GTP Phosphohydrolases - genetics
- Gene Frequency -
- Genetic Predisposition to Disease - epidemiology Genetic Predisposition to Disease - genetics
- Genotype -
- Humans -
- Male -
- Melanoma - epidemiology Melanoma - genetics
- Membrane Proteins - genetics
- Middle Aged -
- Phenotype -
- Proto-Oncogene Proteins B-raf - genetics
- Receptor, Melanocortin, Type 1 - genetics
- Skin Neoplasms - epidemiology Skin Neoplasms - genetics
- Skin Neoplasms - epidemiology