Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Pocivalnik, M; Kirsch, AH; Hassler, EM; Rosenkranz, AR; Eller, K.
Fever and pneumonitis induced by enteric-coated mycophenolate sodium in a patient after kidney transplantation.
Transpl Int. 2013; 26(7):e54-e57
Doi: 10.1111/tri.12104
(- Case Report)
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- Führende Autor*innen der Med Uni Graz
- Eller Kathrin
- Kirsch Alexander
- Ribitsch Mirjam
- Co-Autor*innen der Med Uni Graz
- Hassler Eva Maria
- Rosenkranz Alexander
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- Abstract:
- Here, we report on a patient after kidney transplantation, who developed fever and pneumonitis due to mycophenolic acid (MPA) treatment. Decreasing MPA dosages improved the symptoms, but after rechallenge with higher MPA doses the symptoms recurred. Discontinuation of MPA resulted in a complete resolution of fever within 24 h and a rapid improvement in pneumonitis. In vitro, the patient's polymorphonuclear neutrophils (PMNs) developed increased oxidative burst when incubated with MPA and N-formyl Met-Leu-Phe. We first report on MPA-induced pneumonitis and show that MPA can induce a pro-inflammatory response in kidney-transplanted patients. These pro-inflammatory changes might be due to paradoxical activation of PMNs.
- Find related publications in this database (using NLM MeSH Indexing)
- Fever - chemically induced
- Humans -
- Immunosuppressive Agents - adverse effects
- Kidney Transplantation -
- Male -
- Mycophenolic Acid - adverse effects
- Neutrophils - drug effects
- Pneumonia - chemically induced
- Respiratory Burst - drug effects
- Tablets, Enteric-Coated -
- Find related publications in this database (Keywords)
- drug-induced fever
- mycophenolate
- neutrophil granulocytes
- pneumonitis