Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Gunn, MD; Kyuwa, S; Tam, C; Kakiuchi, T; Matsuzawa, A; Williams, LT; Nakano, H.
Mice lacking expression of secondary lymphoid organ chemokine have defects in lymphocyte homing and dendritic cell localization.
J Exp Med. 1999; 189(3):451-460
Doi: 10.1084/jem.189.3.451
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- Tam-Amersdorfer Carmen
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- Abstract:
- Secondary lymphoid organ chemokine (SLC) is expressed in high endothelial venules and in T cell zones of spleen and lymph nodes (LNs) and strongly attracts naive T cells. In mice homozygous for the paucity of lymph node T cell (plt) mutation, naive T cells fail to home to LNs or the lymphoid regions of spleen. Here we demonstrate that expression of SLC is undetectable in plt mice. In addition to the defect in T cell homing, we demonstrate that dendritic cells (DCs) fail to accumulate in spleen and LN T cell zones of plt mice. DC migration to LNs after contact sensitization is also substantially reduced. The physiologic significance of these abnormalities in plt mice is indicated by a markedly increased sensitivity to infection with murine hepatitis virus. The plt mutation maps to the SLC locus; however, the sequence of SLC introns and exons in plt mice is normal. These findings suggest that the abnormalities in plt mice are due to a genetic defect in the expression of SLC and that SLC mediates the entry of naive T cells and antigen-stimulated DCs into the T cell zones of secondary lymphoid organs.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Antigen Presentation -
- Cell Movement -
- Chemokine CCL19 -
- Chemokine CCL21 -
- Chemokines, CC - biosynthesis Chemokines, CC - deficiency Chemokines, CC - genetics Chemokines, CC - immunology
- Chemotaxis, Leukocyte -
- Coronavirus Infections - immunology
- Dendritic Cells - cytology Dendritic Cells - immunology
- Epidermis - immunology
- Hepatitis, Viral, Animal - immunology
- Immune System - abnormalities
- Lymph Nodes - immunology
- Mice -
- Mice, Mutant Strains -
- Murine hepatitis virus - immunology Murine hepatitis virus - pathogenicity
- RNA, Messenger - isolation & purification
- Receptors, CCR7 -
- Receptors, Chemokine - metabolism
- Spleen - immunology
- T-Lymphocytes - cytology T-Lymphocytes - immunology
- Find related publications in this database (Keywords)
- CC chemokines
- cellular immunity
- leukocyte chemotaxis
- T lymphocytes
- mutation