Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Ropposch, T; Steger, B; Meço, C; Emesz, M; Reitsamer, H; Rasp, G; Moser, G.
The effect of steroids in combination With optic nerve decompression surgery in traumatic optic neuropathy.
Laryngoscope. 2013; 123(5):1082-1086
Doi: 10.1002/lary.23845
Web of Science
PubMed
FullText
FullText_MUG
- Leading authors Med Uni Graz
- Ropposch Thorsten
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- Objectives/Hypothesis: Traumatic optic neuropathy (TON) is an important cause of severe visual impairment following blunt or penetrating head trauma. Treatment options include steroids, decompression, or both. Studies have failed to show a clear benefit for either steroids or surgery or a combined therapy. This study describes the visual outcome in surgically managed patients with or without steroid treatment. Study Design: Retrospective analysis. Methods: In a retrospective chart review we included patients (n = 42) with TON who were managed with optic nerve decompression surgery with or without steroids. Comparison of initial and final visual acuity was the primary outcome parameter. Results: In 42 consecutive patients, steroids were used in 21 cases (50%). Ten patients received a high-dose systemic regimen of more than 500 mg methylprednisolone initial dose, and 11 patients were treated with a lower dose. The overall visual improvement rate was 33%, no change was noted in 50%, and no outcome data were available in 17%. The visual improvement rate of patients treated with decompression surgery and steroids was lower (29%, 6 of 21) than those treated with surgery alone (53%, 8 of 15). Comparing both groups, additional steroids had no beneficial effect on the visual outcome (P = .97). There was no case with a deterioration of visual function due to therapy. Conclusions: In patients with traumatic optic neuropathy who were treated with optic nerve decompression surgery, steroids had no beneficial effect on the visual outcome.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Decompression, Surgical - methods
- Dose-Response Relationship, Drug -
- Female -
- Follow-Up Studies -
- Glucocorticoids - administration & dosage
- Humans -
- Male -
- Methylprednisolone - administration & dosage
- Middle Aged -
- Neurosurgical Procedures - methods
- Optic Nerve - drug effects Optic Nerve - physiopathology Optic Nerve - surgery
- Optic Nerve Injuries - drug therapy Optic Nerve Injuries - physiopathology Optic Nerve Injuries - surgery
- Retrospective Studies -
- Treatment Outcome -
- Visual Acuity -
- Find related publications in this database (Keywords)
- Optic nerve injury
- surgical treatment
- drug therapy
- steroids
- visual acuity