Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Lerchbaum, E; Pilz, S; Grammer, TB; Boehm, BO; Stojakovic, T; Obermayer-Pietsch, B; März, W.
The fatty liver index is associated with increased mortality in subjects referred to coronary angiography.
Nutr Metab Cardiovasc Dis. 2013; 23(12):1231-1238
Doi: 10.1016/j.numecd.2013.02.004
[OPEN ACCESS]
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Lerchbaum Elisabeth
- Co-Autor*innen der Med Uni Graz
- März Winfried
- Obermayer-Pietsch Barbara
- Pilz Stefan
- Stojakovic Tatjana
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- Fatty liver index (FLI), a surrogate parameter for nonalcoholic fatty liver disease, is an emerging risk factor for cardiovascular diseases and mortality. We aimed to evaluate whether FLI is associated with all-cause, cardiovascular, and non-cardiovascular mortality as well as fatal cancer in a cohort of subjects routinely referred to coronary angiography. FLI was calculated using BMI (body mass index), waist circumference (WC), triglycerides (TG) and gamma-glutamyl transferase (GGT) in 3270 subjects who were referred to coronary angiography (1997-2000). The main outcome measures were Cox proportional hazard ratios (HRs) for mortality from all causes, cardiovascular causes, non-cardiovascular causes, and fatal cancer. After a median follow-up time of 7.7 years, 740 subjects (22.6%) had died. There were 437 deaths due to cardiovascular disease and 303 deaths due to non-cardiovascular disease. Age-, sex-, and BMI-adjusted HRs (with 95% confidence intervals) for all-cause, cardiovascular, and non-cardiovascular mortality in the highest compared to the lowest FLI quartile were 2.56 (1.90-3.43; p < 0.001), 2.17 (1.47-3.22; p < 0.001), and 3.49 (2.16-5.66; p < 0.001), respectively. In age-, sex-, and BMI-adjusted analyzes, we found no significant association of FLI with fatal cancer. Multivariate adjusted HRs for all-cause, cardiovascular, non-cardiovascular mortality, and fatal cancer in the highest compared to the lowest FLI quartile were 2.17 (1.58-2.99; p < 0.001), 1.64 (1.07-2.51; p = 0.023), 3.72 (2.22-6.24; p < 0.001), and 2.33 (1.01-5.41; p = 0.048) respectively. In subjects referred to coronary angiography, high FLI levels are independently associated with increased all-cause, cardiovascular, and non-cardiovascular mortality as well as fatal cancer. © 2013 Elsevier B.V. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Body Mass Index -
- Cardiovascular Diseases - blood
- Cerebrovascular Disorders - blood
- Coronary Angiography -
- Fatty Liver - complications
- Female -
- Follow-Up Studies -
- Humans -
- Logistic Models -
- Male -
- Middle Aged -
- Multivariate Analysis -
- Non-alcoholic Fatty Liver Disease -
- Prospective Studies -
- Risk Factors -
- Triglycerides - blood
- Waist Circumference -
- gamma-Glutamyltransferase - blood
- Find related publications in this database (Keywords)
- Nonalcoholic fatty liver disease
- Hepatic steatosis
- Cardiovascular disease
- All-cause mortality
- Non-cardiovascular mortality