Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Marx, N; Silbernagel, G; Brandenburg, V; Burgmaier, M; Kleber, ME; Grammer, TB; Winkelmann, BR; Boehm, BO; März, W.
C-peptide levels are associated with mortality and cardiovascular mortality in patients undergoing angiography: the LURIC study.
Diabetes Care. 2013; 36(3):708-714
Doi: 10.2337/dc12-1211
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- Führende Autor*innen der Med Uni Graz
- Silbernagel Günther
- Co-Autor*innen der Med Uni Graz
- März Winfried
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- Abstract:
- C-peptide is a proinsulin cleavage product released from the pancreas in amounts equimolar to insulin, and elevated levels of C-peptide have been found in patients with insulin resistance and early type 2 diabetes mellitus. Recent data suggest that C-peptide could play a causal role in the pathophysiology of vascular disease, but nothing is known about the prognostic value of C-peptide concentrations in the circulation. We examined whether C-peptide is associated with cardiovascular and total mortality in 2,306 patients from the Ludwigshafen Risk and Cardiovascular Health Study who underwent coronary angiography at baseline (1997-2000). During a mean follow-up of 7.6 years, 440 deaths (19.1%) occurred, 252 (10.9%) of which were due to cardiovascular causes. Age- and sex-adjusted hazard ratios (HRs) in the third compared with the first tertile of C-peptide were 1.46 (95% CI 1.15-1.85; P = 0.002) for all cause and 1.58 (1.15-2.18; P = 0.005) for cardiovascular mortality. After further adjustment for common risk factors as well as markers of glucose metabolism, these HRs remained significant at 1.46 (1.10-1.93; P = 0.008) and 1.55 (1.07-2.24; P = 0.022), respectively. Moreover, patients in higher tertiles of C-peptide exhibited higher levels of markers of endothelial dysfunction and atherosclerosis as well as a more severe extent of coronary lesions. In patients undergoing coronary angiography, C-peptide levels are independently associated with all cause and cardiovascular mortality as well as presence and severity of coronary artery disease. Further studies are needed to examine a potential causal role of C-peptide in atherogenesis in humans.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Arteriosclerosis - blood Arteriosclerosis - mortality Arteriosclerosis - pathology
- C-Peptide - blood
- Cardiovascular Diseases - blood Cardiovascular Diseases - mortality Cardiovascular Diseases - pathology
- Coronary Angiography -
- Female -
- Humans -
- Male -
- Middle Aged -
- Mortality -