Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Reif, P; Tappauf, C; Panzitt, T; Haas, J; Lang, U; Klaritsch, P.
Efficacy of misoprostol in relation to uterine position in the treatment of early pregnancy failure.
Int J Gynaecol Obstet. 2013; 121(2):137-140
Doi: 10.1016/j.ijgo.2012.11.019
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Reif Philipp
- Co-Autor*innen der Med Uni Graz
- Haas Josef
- Klaritsch Philipp
- Lang Uwe
- Schöll Carmen
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- Abstract:
- Objective: To evaluate the efficacy of misoprostol in the treatment of missed or incomplete abortion in relation to uterine position. Methods: In a retrospective cohort study, misoprostol was evaluated as first-line treatment for missed and incomplete abortion before 13 gestational weeks. Between 2009 and 2011, women received 600 mu g of sublingual misoprostol for missed abortion or 400 jig for incomplete abortion. Follow-up examinations were performed 7-10 days later, with the option of a second administration of misoprostol. Success-was defined by the absence of vaginal bleeding or sonographic signs of incomplete abortion, and falling levels of beta-human chorionic gonadotropin. Results: In total, 111 women were included in the study. A single-dose regimen was effective for 73 (65.8%) women. The overall success rate, including repeat doses, was 73.0% (81/111). There were no significant differences in treatment success between women with missed abortion and those with incomplete abortion (56/89 [62.9%] vs 18/22 [81.8%]; P=0.152). Anteverted uterine position was associated with significantly higher success rates compared with diverging position (62/86 [72.1%] vs 4/18 [22.2%]; P=0.001). Conclusion: Misoprostol is an effective treatment for early pregnancy failure. Uterine position might impact the success of medical treatment for missed abortion. (C) 2013 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Abortifacient Agents, Nonsteroidal - administration & dosage Abortifacient Agents, Nonsteroidal - therapeutic use
- Abortion, Incomplete - drug therapy
- Abortion, Missed - drug therapy
- Adult -
- Cohort Studies -
- Dose-Response Relationship, Drug -
- Female -
- Follow-Up Studies -
- Humans -
- Misoprostol - administration & dosage Misoprostol - therapeutic use
- Pregnancy -
- Retrospective Studies -
- Treatment Outcome -
- Uterus - metabolism
- Find related publications in this database (Keywords)
- Incomplete abortion
- Misoprostol
- Missed abortion
- Outcome
- Spontaneous abortion
- Uterine position