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SHR Neuro Cancer Cardio Lipid Metab Microb

Reiter, G; Reiter, U; Wagner, T; Kozma, N; Roland, J; Schöllnast, H; Ebner, F; Lanzer, G.
Thermometry of red blood cell concentrate: magnetic resonance decoding warm up process.
PLoS One. 2013; 8(2):e57931 Doi: 10.1371/journal.pone.0057931 [OPEN ACCESS]
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Leading authors Med Uni Graz: Reiter Gert; Reiter Ursula
Co-authors Med Uni Graz: Ebner Franz; Kozma Noemi; Lanzer Gerhard; Schoellnast Helmut; Wagner Thomas
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Abstract:: PURPOSE: Temperature is a key measure in human red blood cell concentrate (RBC) quality control. A precise description of transient temperature distributions in RBC units removed from steady storage exposed to ambient temperature is at present unknown. Magnetic resonance thermometry was employed to visualize and analyse RBC warm up processes, to describe time courses of RBC mean, surface and core temperatures by an analytical model, and to determine and investigate corresponding model parameters. METHODS: Warm-up processes of 47 RBC units stored at 1-6°C and exposed to 21.25°C ambient temperature were investigated by proton resonance frequency thermometry. Temperature distributions were visualized and analysed with dedicated software allowing derivation of RBC mean, surface and core temperature-time courses during warm up. Time-dependence of mean temperature was assumed to fulfil a lumped capacitive model of heat transfer. Time courses of relative surface and core temperature changes to ambient temperature were similarly assumed to follow shifted exponential decays characterized by a time constant and a relative time shift, respectively. RESULTS: The lumped capacitive model of heat transfer and shifted exponential decays described time-dependence of mean, surface and core temperatures close to perfect (mean R(2) were 0.999±0.001, 0.996±0.004 and 0.998±0.002, respectively). Mean time constants were τmean = 55.3±3.7 min, τsurface = 41.4±2.9 min and τcore = 76.8±7.1 min, mean relative time shifts were Δsurface = 0.07±0.02 and Δcore = 0.04±0.01. None of the constants correlated significantly with temperature differences between ambient and storage temperature. CONCLUSION: Lumped capacitive model of heat transfer and shifted exponential decays represent simple analytical formulas to describe transient mean, surface and core temperatures of RBC during warm up, which might be a helpful tool in RBC temperature monitoring and quality control. Independence of constants on differences between ambient and storage temperature suggests validity of models for arbitrary storage and ambient temperatures.
Find related publications in this database (using NLM MeSH Indexing): Erythrocytes - administration & dosage; Humans - administration & dosage; Protons - administration & dosage; Specimen Handling - administration & dosage; Temperature - administration & dosage; Thermometry - methods; Time Factors - administration & dosage