Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Schoellnast, H; Monette, S; Ezell, PC; Keene, A; Quehenberger, F; Erinjeri, JP; Solomon, SB.
Interstitial laser-induced thermotherapy of the lung: evaluation of the influence of ablation continuity on ablation size in a swine model.
Cancer Imaging. 2013; 13(3):8-13
Doi: 10.1102/1470-7330.2013.0002
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- Führende Autor*innen der Med Uni Graz
- Schoellnast Helmut
- Co-Autor*innen der Med Uni Graz
- Quehenberger Franz
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- Abstract:
- The purpose of this study was to assess the relationship between size and the continuity of energy application in interstitial laser-induced thermotherapy. Percutaneous computed tomography-guided laser ablation (30 W, 600 nm diode) of the lung was performed in 7 Yorkshire pigs; a total of 42 ablation zones were created. Twenty ablations were performed using a continuous cycle of 2 min (protocol A) and 22 ablations were performed using 4 intermittent cycles with a duration of 1 min for each cycle interrupted by a 10-s stop between the cycles (protocol B). The lung was harvested immediately after euthanasia for gross pathology and histopathologic evaluation. Statistical analysis was performed using the Student t test and the Spearman correlation coefficient. Laser ablation resulted in complete necrosis of variable size of lung. The mean ablation zone dimensions (±SD) were 1.9 (±0.4) cm × 1.4 (±0.3) cm for protocol A and 2.2 (±0.5) cm × 1.4 (±0.4) cm for protocol B. The size of the necrosis is not significantly different when comparing a continuous 2-min ablation to a 4-cycle intermittent ablation for 1 min each cycle interrupted by a 10-s stop between the cycles (P = 0.98 and 0.53, respectively).
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Hyperthermia, Induced -
- Laser Therapy -
- Lung - pathology
- Necrosis -
- Swine -
- Tomography, X-Ray Computed -
- Find related publications in this database (Keywords)
- Laser ablation
- laser-induced therapy
- LITT
- thermal ablation
- lung