Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Wonisch, W; Schaur, RJ; Bilinski, T; Esterbauer, H.
Assessment of growth inhibition by aldehydic lipid peroxidation products and related aldehydes by Saccharomyces cerevisiae.
Cell Biochem Funct. 1995; 13(2):91-98
Doi: 10.1002/cbf.290130205
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Wonisch Willibald
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- Abstract:
- The effect of pretreatment with aldehydes on the subsequent colony forming efficiency (CFE) of Saccharomyces cerevisiae was investigated. All 21 aldehydes tested inhibited CFE in a dose-dependent manner. The effective doses, however, differed markedly from 300 mM to 0.07 mM depending on the functional groups and chain length of the aldehydes. Amongst the nine representatives of n-alkanals, formaldehyde was the most potent inhibitor, reducing CFE to 50 per cent at a dose of 0.3 mM (IC50). In the series of 2-trans-alkenals, acrolein was most effective with an IC50 of 0.08 mM and amongst the 4-hydroxy 2-trans-alkenals, 4-hydroxynonenal was most effective with IC50 of 0.07 mM. In general, effectiveness decreased in the order: 4-hydroxyalkenals > 2-alkenals > n-alkenals. It is proposed that S. cerevisiae is a promising target cell to elucidate further the molecular mechanisms by which aldehydes, particularly the lipid peroxidation product 4-hydroxynonenal, inhibits cell proliferation.
- Find related publications in this database (using NLM MeSH Indexing)
- Aldehydes - metabolism Aldehydes - toxicity
- Colony Count, Microbial -
- Dose-Response Relationship, Drug -
- Lipid Peroxidation -
- Lipid Peroxides - metabolism Lipid Peroxides - toxicity
- Saccharomyces cerevisiae - drug effects
- Toxicity Tests -
- Find related publications in this database (Keywords)
- ALDEHYDES
- COLONY FORMING EFFICIENCY
- LIPID PEROXIDATION
- SACCHAROMYCES CEREVISIAE
- 4-HYDROXYNONENAL