Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Yasmin, N; Konradi, S; Eisenwort, G; Schichl, YM; Seyerl, M; Bauer, T; Stöckl, J; Strobl, H.
β-Catenin promotes the differentiation of epidermal Langerhans dendritic cells.
J Invest Dermatol. 2013; 133(5):1250-1259
Doi: 10.1038/jid.2012.481
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- Führende Autor*innen der Med Uni Graz
- Strobl Herbert
- Co-Autor*innen der Med Uni Graz
- Bauer Thomas
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- Abstract:
- The epithelial signaling protein and transcriptional regulator β-catenin has recently been implicated in hematopoietic dendritic cell (DC) differentiation as well as in DC-mediated tolerance. We here observed that epidermal Langerhans cells (LCs) but not interstitial/dermal DCs express detectable β-catenin. LCs are unique among the DC family members in that LC networks critically depend on epithelial adhesion molecules as well as on the cytokine transforming growth factor-β1 (TGF-β1). However, despite the important functions of LCs in the immune system, the molecular mechanisms governing LC differentiation and maintenance remain poorly defined. We found that TGF-β1 induces β-catenin in progenitor cells undergoing LC differentiation and that β-catenin promotes LC differentiation. Vitamin D, another epidermal signal, enhanced TGF-β1-mediated β-catenin induction and promoted the expression of multiple epithelial genes by LCs. Moreover, full-length vitamin D receptor (VDR) promoted, whereas a truncated VDR diminished, the positive effects of ectopic β-catenin on LC differentiation. Therefore, we here identified β-catenin as a positive regulator of LC differentiation in response to TGF-β1 and identified a functional interaction between β-catenin and VDR in these cells.
- Find related publications in this database (using NLM MeSH Indexing)
- Cadherins - metabolism
- Cell Differentiation - drug effects
- Cells, Cultured -
- Epidermis - cytology
- Hematopoietic Stem Cells - cytology
- Humans -
- Langerhans Cells - cytology
- Receptors, Calcitriol - metabolism
- Signal Transduction - physiology
- Transforming Growth Factor beta1 - pharmacology
- Vitamin D - pharmacology
- beta Catenin - metabolism