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Neubauer, H; Pabst, T; Dick, A; Machann, W; Evangelista, L; Wirth, C; Köstler, H; Hahn, D; Beer, M.
Small-bowel MRI in children and young adults with Crohn disease: retrospective head-to-head comparison of contrast-enhanced and diffusion-weighted MRI.
Pediatr Radiol. 2013; 43(1):103-114 Doi: 10.1007/s00247-012-2492-1
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Co-authors Med Uni Graz: Beer Meinrad
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Abstract:: Background Small-bowel MRI based on contrast-enhanced T1-weighted sequences has been challenged by diffusion-weighted imaging (DWI) for detection of inflammatory bowel lesions and complications in patients with Crohn disease. Objective To evaluate free-breathing DWI, as compared to contrast-enhanced MRI, in children, adolescents and young adults with Crohn disease. Materials and methods This retrospective study included 33 children and young adults with Crohn disease ages 17+/-3 years (mean +/- standard deviation) and 27 matched controls who underwent small-bowel MRI with contrast-enhanced T1-weighted sequences and DWI at 1.5 T. The detectability of Crohn manifestations was determined. Concurrent colonoscopy as reference was available in two-thirds of the children with Crohn disease. Results DWI and contrast-enhanced MRI correctly identified 32 and 31 patients, respectively. All 22 small-bowel lesions and all Crohn complications were detected. False-positive findings (two on DWI, one on contrast-enhanced MRI), compared to colonoscopy, were a result of large-bowel lumen collapse. Inflammatory wall thickening was comparable on DWI and contrast-enhanced MRI. DWI was superior to contrast-enhanced MRI for detection of lesions in 27% of the assessed bowel segments and equal to contrast-enhanced MRI in 71% of segments. Conclusion DWI facilitates fast, accurate and comprehensive workup in Crohn disease without the need for intravenous administration of contrast medium. Contrast-enhanced MRI is superior in terms of spatial resolution and multiplanar acquisition.
Find related publications in this database (using NLM MeSH Indexing): Adolescent -; Adult -; Case-Control Studies -; Child -; Colonoscopy -; Contrast Media -; Crohn Disease - pathology; Diffusion Magnetic Resonance Imaging -; Female -; Humans -; Intestine, Small - pathology; Lymphatic Diseases - pathology; Magnetic Resonance Imaging - methods; Male -; Retrospective Studies -; Young Adult -
Find related publications in this database (Keywords): Crohn disease; Diffusion-weighted imaging; Paediatric; Contrast medium; MRI