Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Beham, A; Kainz, J; Stammberger, H; Auböck, L; Beham-Schmid, C.
Immunohistochemical and electron microscopical characterization of stromal cells in nasopharyngeal angiofibromas.
Eur Arch Otorhinolaryngol. 1997; 254(4):196-199
Doi: 10.1007/BF00879273
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- Führende Autor*innen der Med Uni Graz
- Beham Alfred
- Co-Autor*innen der Med Uni Graz
- Beham-Schmid Christine
- Kainz Josef
- Stammberger Heinz
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- Abstract:
- Twenty-eight cases of nasopharyngeal angiofibroma were studied immunohistochemically for cytoskeletal phenotyping of stromal cells. Electron microscopy was also used to study the ultrastructure of five of the tumors. All typical stromal cells showed intensive immunostaining for vimentin, but were negative for smooth muscle actin and desmin. Ultrastructurally, most of these cells appeared to be exclusively fibroblasts. However, in some areas stromal cells were seen that morphologically resembled myofibroblasts by their shapes and arrangement, and were characterized by the coexpression of vimentin and smooth muscle actin. Electron microscopy confirmed their myofibroblastic nature. The present study showed that the typical stromal cells in nasopharyngeal angiofibromas were fibroblasts and not myofibroblasts. In these tumors myofibroblasts occurred only focally, in connection with fibrotic areas and exclusively as a vimentin+/actin+cytoskeletal phenotype. This indicates that myofibroblasts are not primary stromal tumor cells in nasopharyngeal angiofibromas, but occur due to regressive changes.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Angiofibroma - pathology
- Child -
- Cytoskeletal Proteins - analysis
- Fibroblasts - pathology
- Humans -
- Immunoenzyme Techniques -
- Male -
- Microscopy, Electron -
- Nasopharyngeal Neoplasms - pathology
- Stromal Cells - pathology
- Tumor Markers, Biological - analysis
- Find related publications in this database (Keywords)
- Nasopharyngeal Angiofibroma
- Ultrastructure
- Myofibroblast
- Immunohistochemistry
- Electron Microscopy