Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Samonigg, H; Wilders-Truschnig, M; Loibner, H; Plot, R; Rot, A; Kuss, I; Werner, G; Stöger, H; Wrann, M; Herlyn, D.
Immune response to tumor antigens in a patient with colorectal cancer after immunization with anti-idiotype antibody.
Clin Immunol Immunopathol. 1992; 65(3):271-277
Doi: 10.1016/0090-1229(92)90157-J
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- Führende Autor*innen der Med Uni Graz
- Samonigg Hellmut
- Co-Autor*innen der Med Uni Graz
- Stöger Herbert
- Truschnig-Wilders Martini
- Werner Georg Alexander
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- Abstract:
- An active vaccination protocol was performed on one patient with colon carcinoma as a pilot to a prospective randomized double-blind clinical trial with the vaccine SDZ SCV 106. This vaccine is an anti-idiotype goat antibody to the monoclonal antibody 17-1A, which is directed against the tumor antigen 17-1A. To study the effect of the therapy on the immune reactivity, several tests were performed to detect anti-tumor antibodies in the serum as well as in eluates of metastatic tissue. Furthermore metastases removed from the lung were examined by immunohistochemistry. The results suggest that the humoral and cellular immune reactivity against the tumor are enhanced.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Antibodies, Anti-Idiotypic - therapeutic use
- Antibodies, Neoplasm - immunology
- Antigens, Tumor-Associated, Carbohydrate - immunology
- Colorectal Neoplasms - therapy
- Humans -
- Immunotherapy -
- Male -
- Neoplasm Metastasis -
- Pilot Projects -
- Vaccination -