Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Resch, B; Resch, E; Müller, W.
Should respiratory care in preterm infants include prophylaxis against respiratory syncytial virus infection? The case in favour.
Paediatr Respir Rev. 2013; 14(2):130-136
Doi: 10.1016/j.prrv.2012.12.005
Web of Science
PubMed
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FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Resch Bernhard
- Co-Autor*innen der Med Uni Graz
- Müller Wilhelm
- Resch-Poteralski Elisabeth
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- Abstract:
- Respiratory syncytial virus (RSV) is the most significant cause of acute respiratory tract infections (RTI) in infants and young children throughout the world. Preterm infants are at increased risk for severe RSV lower respiratory tract infection due to small lung volumes, a reduced lung surface area, small airways and an increased air space wall thickness. Additionally, the airways of preterm infants have been ventilated mechanically and suctioned and potentially damaged by many microtraumas with disruption of endothelial surfaces enabling pathogens to invade more easily. The immune system of preterm infants is immature resulting in low antibody titers (incomplete transplacental transfer of maternal antibodies) and a reduced cellular immunity with reduced viral clearance. Rehospitalization rates of preterm compared to term infants due to RSV infection are increased as are total morbidity and mortality associated with RSV disease. Palivizumab effectively reduces RSV related rehospitalisation in this high-risk population. Copyright © 2013 Elsevier Ltd. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Humans -
- Infant -
- Infant, Premature -
- Infant, Premature, Diseases - epidemiology
- Respiratory Care Units -
- Respiratory Syncytial Virus Infections - epidemiology
- Respiratory Syncytial Viruses - immunology
- Viral Vaccines - therapeutic use
- Find related publications in this database (Keywords)
- Respiratory syncytial virus
- Lower respiratory tract infection
- Preterm infant
- Risk factors