Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Uranüs, S; Bretthauer, G; Nagele-Moser, D; Saliba, S; Tomasch, G; Rafolt, D; Justich, I; Waldert, J; Berghold, A; Kleinert, R; Becker, H; Voges, U; Wiederstein-Grasser, I; Koch, H.
New Synthetic Prosthesis for Peripheral Nerve Injuries: An Experimental Pilot Study.
Surg Innov. 2013; 20(2):171-175
Doi: 10.1177/1553350612458546
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Uranüs Selman
- Co-Autor*innen der Med Uni Graz
- Berghold Andrea
- Justich Ivo
- Kleinert Reinhold
- Koch Horst
- Thaler-Saliba Sarah
- Tomasch Gordana
- Wiederstein-Grasser Iris
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- Abstract:
- Introduction. Even the most modern technology has failed to induce satisfactory functional regeneration of traumatically severed peripheral nerves. Delayed neural regeneration and in consequence, slower neural conduction seriously limit muscle function in the area supplied by the injured nerve. This study aimed to compare a new nerve coaptation system involving an innovative prosthesis with the classical clinical method of sutured nerve coaptation. Besides the time and degree of nerve regeneration, the influence of electrostimulation was also tested. Methods. The sciatic nerve was severed in 14 female Gottingen minipigs with an average weight of 40.4 kg. The animals were randomized into 2 groups: One group received the new prosthesis and the other underwent microsurgical coaptation. In each group, according to the randomization a part of the animals received postoperative electrostimulation. Postoperative monitoring and the stimulation schedule covered a period of 9 months, during which axonal budding was evaluated monthly. Results. The data from the pilot study indicate that results with the nerve prosthesis were comparable with those of conventional coaptation. Conclusion. The results indicate that implantation of the nerve prosthesis allows for good and effective neural regeneration. This new and simple treatment option for peripheral nerve injuries can be performed in any hospital with surgical facilities as it does not involve the demanding microsurgical suture technique that can only be performed in specialized centers.
- Find related publications in this database (using NLM MeSH Indexing)
- Action Potentials - physiology
- Animals -
- Biomedical Engineering - instrumentation
- Electric Stimulation Therapy -
- Female -
- Muscle, Skeletal - physiology
- Nerve Regeneration - physiology
- Neural Prostheses -
- Peripheral Nerve Injuries - surgery
- Peripheral Nerves - surgery
- Pilot Projects -
- Swine -
- Swine, Miniature -
- Tissue Engineering - instrumentation
- Find related publications in this database (Keywords)
- neurosurgery
- orthopedic surgery
- biomedical engineering
- tissue engineering